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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Lck-cre)I540Jxm
transgene insertion I540, Jamey Marth
MGI:3701502
Summary 3 genotypes


Genotype
MGI:5302532
cn1
Allelic
Composition		 Efnb1tm1.1Jwu/Efnb1tm1.1Jwu
Tg(Lck-cre)I540Jxm/0
Genetic
Background		 B6.Cg-Efnb1tm1.1Jwu Tg(Lck-cre)I540Jxm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1.1Jwu mutation (0 available); any Efnb1 mutation (15 available)
Tg(Lck-cre)I540Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:178148 )
N
• mice exhibit normal lymphoid organ size and histology and thymocyte development




Genotype
MGI:5302540
cn2
Allelic
Composition		 Efnb1tm1.1Jwu/Efnb1tm1.1Jwu
Efnb2tm1.1Jwu/Efnb2tm1.1Jwu
Tg(Lck-cre)I540Jxm/0
Genetic
Background		 B6.Cg-Efnb2tm1.1Jwu Efnb1tm1.1Jwu Tg(Lck-cre)I540Jxm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1.1Jwu mutation (0 available); any Efnb1 mutation (15 available)
Efnb2tm1.1Jwu mutation (0 available); any Efnb2 mutation (29 available)
Tg(Lck-cre)I540Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Decreased thymus and spleen weight and cellularity in Efnb1tm1.1Jwu/Efnb1tm1.1Jwu Efnb2tm1.1Jwu/Efnb2tm1.1Jwu Tg(Lck-cre)I540Jxm/0 mice

immune system
increased thymocyte apoptosis ( J:178148 )
• in all subpopulations
abnormal T cell differentiation ( J:178148 )
• progression from DN3 to DN4 is impaired compared to in wild-type mice
decreased T cell number ( J:178148 )
• in the spleen and lymph nodes
• however, the number of memory and regulatory T cells in the spleen and lymph nodes is normal
decreased CD4-positive, alpha-beta T cell number ( J:178148 )
• in the thymus, spleen, and lymph nodes
decreased CD8-positive, alpha-beta T cell number ( J:178148 )
• in the thymus, spleen, and lymph nodes

cellular
increased thymocyte apoptosis ( J:178148 )
• in all subpopulations

hematopoietic system
increased thymocyte apoptosis ( J:178148 )
• in all subpopulations
abnormal T cell differentiation ( J:178148 )
• progression from DN3 to DN4 is impaired compared to in wild-type mice
abnormal bone marrow cell morphology/development ( J:178148 )
• in transplantation experiments, bone marrow cells exhibit impaired development and expansion and mature T cells in irradiated recipients compared with wild-type cells
decreased T cell number ( J:178148 )
• in the spleen and lymph nodes
• however, the number of memory and regulatory T cells in the spleen and lymph nodes is normal
decreased CD4-positive, alpha-beta T cell number ( J:178148 )
• in the thymus, spleen, and lymph nodes
decreased CD8-positive, alpha-beta T cell number ( J:178148 )
• in the thymus, spleen, and lymph nodes

endocrine/exocrine glands
increased thymocyte apoptosis ( J:178148 )
• in all subpopulations




Genotype
MGI:5302533
cn3
Allelic
Composition		 Efnb2tm1.1Jwu/Efnb2tm1.1Jwu
Tg(Lck-cre)I540Jxm/0
Genetic
Background		 B6.Cg-Efnb2tm1.1Jwu Tg(Lck-cre)I540Jxm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb2tm1.1Jwu mutation (0 available); any Efnb2 mutation (29 available)
Tg(Lck-cre)I540Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:178148 )
N
• mice exhibit normal lymphoid organ size and histology and thymocyte development




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory