immune system
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• mice exhibit normal lymphoid organ size and histology and thymocyte development
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Allele Symbol Allele Name Allele ID |
Tg(Lck-cre)I540Jxm transgene insertion I540, Jamey Marth MGI:3701502 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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• mice exhibit normal lymphoid organ size and histology and thymocyte development
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
Decreased thymus and spleen weight and cellularity in Efnb1tm1.1Jwu/Efnb1tm1.1Jwu Efnb2tm1.1Jwu/Efnb2tm1.1Jwu Tg(Lck-cre)I540Jxm/0 mice
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• in all subpopulations
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• progression from DN3 to DN4 is impaired compared to in wild-type mice
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• impaired
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• impaired
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• in the spleen and lymph nodes
• however, the number of memory and regulatory T cells in the spleen and lymph nodes is normal
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• in the thymus, spleen, and lymph nodes
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• in the thymus, spleen, and lymph nodes
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• in mice infected with LCMV
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• in all subpopulations
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• in all subpopulations
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• progression from DN3 to DN4 is impaired compared to in wild-type mice
|
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• impaired
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• impaired
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• in transplantation experiments, bone marrow cells exhibit impaired development and expansion and mature T cells in irradiated recipients compared with wild-type cells
|
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• in the spleen and lymph nodes
• however, the number of memory and regulatory T cells in the spleen and lymph nodes is normal
|
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• in the thymus, spleen, and lymph nodes
|
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• in the thymus, spleen, and lymph nodes
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|
|
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• in all subpopulations
|
|
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice exhibit normal lymphoid organ size and histology and thymocyte development
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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