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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sle21129P2/Ola
129P2/Ola
MGI:3701662
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Fcgr3tm1Jsv/Fcgr3tm1Jsv
Sle21129P2/Ola/Sle21129P2/Ola 		B6.129P2-Fcgr3tm1Jsv MGI:5427952
cx2
 		Fcgr2btm1Ttk/Fcgr2btm1Ttk
Sle21129P2/Ola/Sle21129P2/Ola 		B6.129S4-Fcgr2btm1Ttk MGI:5427951
cx3
 		Fcgr2btm1Ttk/Fcgr2btm1.2Jsv
Sle21129P2/Ola/Sle21C57BL/6 		involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N MGI:5427953
cx4
 		C1qatm1Mjw/C1qatm1Mjw
Sle21129P2/Ola/Sle21129P2/Ola 		involves: 129P2/Ola * 129S/SvEv * C57BL/6 MGI:3701669
cx5
 		C1qatm1Mjw/C1qatm1Mjw
Sle21129P2/Ola/Sle21C57BL/6 		involves: 129P2/Ola * 129S/SvEv * C57BL/6 MGI:3701670
cx6
 		C1qatm1Mjw/C1qatm1Mjw
Sle21129P2/Ola/?
Sle18C57BL/6/Sle18C57BL/6 		involves: 129P2/Ola * 129S/SvEv * C57BL/6 MGI:3701673


Genotype
MGI:5427952
cx1
Allelic
Composition		 Fcgr3tm1Jsv/Fcgr3tm1Jsv
Sle21129P2/Ola/Sle21129P2/Ola
Genetic
Background		 B6.129P2-Fcgr3tm1Jsv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr3tm1Jsv mutation (5 available); any Fcgr3 mutation (28 available)
Sle21129P2/Ola mutation (0 available); any Sle21 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:179175 )
N
• mice exhibit normal mortality

immune system
increased B cell number ( J:179175 )
• increased activated B cell

hematopoietic system
increased B cell number ( J:179175 )
• increased activated B cell

growth/size/body
enlarged spleen ( J:179175 )
increased spleen weight ( J:179175 )




Genotype
MGI:5427951
cx2
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1Ttk
Sle21129P2/Ola/Sle21129P2/Ola
Genetic
Background		 B6.129S4-Fcgr2btm1Ttk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Sle21129P2/Ola mutation (0 available); any Sle21 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:179175 )
• at 8 and 12 months, mice develop fatal glomerular damage unlike wild-type mice

immune system
enlarged spleen ( J:179175 )
• spontaneously
increased spleen weight ( J:179175 )
• spontaneously
abnormal adaptive immunity ( J:179175 )
• mice exhibit increased antibody response after immunization, in mast cell-mediated cutaneous anaphylaxis, and in phagocytosis of immune complex (IC) by macrophages compared with control mice
increased immunoglobulin level ( J:179175 )
• kidney IgG and C3 depositions in a nephrotoxic nephritis model
increased IgG2a level ( J:179175 )
• in a nephrotoxic nephritis model that is more severe than in Fcgr2btm1.2Sjv homozygotes
increased susceptibility to induced arthritis ( J:179175 )
• collagen or K/BXN serum-induced that is more severe than in Fcgr2btm1.2Sjv homozygotes
increased autoantibody level ( J:179175 )
• spontaneous increase in Coombs, chromatin, double-strand DNA, single-strand DNA and histone autoantibodies
kidney inflammation ( J:179175 )
• in a nephrotoxic nephritis model that is more severe than in Fcgr2btm1.2Sjv homozygotes

renal/urinary system
albuminuria ( J:179175 )
• in a nephrotoxic nephritis model
kidney inflammation ( J:179175 )
• in a nephrotoxic nephritis model that is more severe than in Fcgr2btm1.2Sjv homozygotes
abnormal renal glomerulus morphology ( J:179175 )
• at 8 and 12 months, mice develop fatal glomerular damage unlike wild-type mice

homeostasis/metabolism
abnormal glomerular capillary thrombosis ( J:179175 )
• in a nephrotoxic nephritis model
albuminuria ( J:179175 )
• in a nephrotoxic nephritis model

skeleton
increased susceptibility to induced arthritis ( J:179175 )
• collagen or K/BXN serum-induced that is more severe than in Fcgr2btm1.2Sjv homozygotes

hematopoietic system
enlarged spleen ( J:179175 )
• spontaneously
increased spleen weight ( J:179175 )
• spontaneously
increased immunoglobulin level ( J:179175 )
• kidney IgG and C3 depositions in a nephrotoxic nephritis model
increased IgG2a level ( J:179175 )
• in a nephrotoxic nephritis model that is more severe than in Fcgr2btm1.2Sjv homozygotes

growth/size/body
enlarged spleen ( J:179175 )
• spontaneously
increased spleen weight ( J:179175 )
• spontaneously




Genotype
MGI:5427953
cx3
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1.2Jsv
Sle21129P2/Ola/Sle21C57BL/6
Genetic
Background		 involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1.2Jsv mutation (1 available); any Fcgr2b mutation (49 available)
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Sle21129P2/Ola mutation (0 available); any Sle21 mutation (0 available)
Sle21C57BL/6 mutation (0 available); any Sle21 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:179175 )
• mice exhibit greater cumulative death compared with wild-type C57BL/6 mice

immune system
enlarged spleen ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes
increased spleen weight ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes
increased anti-chromatin antibody level ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes
increased anti-histone antibody level ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes

renal/urinary system
albuminuria ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes
abnormal kidney morphology ( J:179175 )
• kidney pathology is increased compared to in wild-type C57BL/6 mice

homeostasis/metabolism
albuminuria ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes

hematopoietic system
enlarged spleen ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes
increased spleen weight ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes

growth/size/body
enlarged spleen ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes
increased spleen weight ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes




Genotype
MGI:3701669
cx4
Allelic
Composition		 C1qatm1Mjw/C1qatm1Mjw
Sle21129P2/Ola/Sle21129P2/Ola
Genetic
Background		 involves: 129P2/Ola * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C1qatm1Mjw mutation (1 available); any C1qa mutation (24 available)
Sle21129P2/Ola mutation (0 available); any Sle21 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system




Genotype
MGI:3701670
cx5
Allelic
Composition		 C1qatm1Mjw/C1qatm1Mjw
Sle21129P2/Ola/Sle21C57BL/6
Genetic
Background		 involves: 129P2/Ola * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C1qatm1Mjw mutation (1 available); any C1qa mutation (24 available)
Sle21129P2/Ola mutation (0 available); any Sle21 mutation (0 available)
Sle21C57BL/6 mutation (0 available); any Sle21 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system




Genotype
MGI:3701673
cx6
Allelic
Composition		 C1qatm1Mjw/C1qatm1Mjw
Sle21129P2/Ola/?
Sle18C57BL/6/Sle18C57BL/6
Genetic
Background		 involves: 129P2/Ola * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C1qatm1Mjw mutation (1 available); any C1qa mutation (24 available)
Sle18C57BL/6 mutation (0 available); any Sle18 mutation (0 available)
Sle21129P2/Ola mutation (0 available); any Sle21 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory