All Phenotypes Gck<tm3Mgn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gck^tm3Mgn
targeted mutation 3, Mark A Magnuson
MGI:3701764

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gck^tm3Mgn/Gck^tm3Mgn	129S6/SvEvTac-Gck^tm3Mgn	MGI:3713301
ht2	Gck^tm3Mgn/Gck⁺	129S6/SvEvTac-Gck^tm3Mgn	MGI:3713300
ht3	Gck^tm3Mgn/Gck⁺	B6.129S6-Gck^tm3Mgn	MGI:3713297

Allelic Composition	Gck^tm3Mgn/Gck^tm3Mgn
Genetic Background	129S6/SvEvTac-Gck^tm3Mgn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gck^tm3Mgn mutation (2 available); any Gck mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:121910 )

• insulin/glucose ratio in fasted adults is significantly greater than in wild-type

abnormal insulin secretion ( J:121910 )

• mice are more sensitive to glucose and islets secret insulin in response to 4.0 mM glucose

decreased circulating glucose level ( J:121910 )

• basal glucose levels are lower than in heterozygotes (57.8 mg/dl vs 78.8 mg/dl)

hypoglycemia ( J:121910 )

• fasted 4-week old mice display mild hypoglycemia

abnormal circulating insulin level ( J:121910 )

• despite lower plasma glucose levels than wild-type, mice have similar plasma insulin levels relative to wild-type; insulin levels are lower than in heterozygous mice (0.32 ng/ml vs 0.45 ng/ml)

decreased glucokinase activity ( J:121910 )

• glucokinase activity is reduced by 71.9% relative to wild-type

endocrine/exocrine glands

abnormal insulin secretion ( J:121910 )

• mice are more sensitive to glucose and islets secret insulin in response to 4.0 mM glucose

Allelic Composition	Gck^tm3Mgn/Gck⁺
Genetic Background	129S6/SvEvTac-Gck^tm3Mgn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gck^tm3Mgn mutation (2 available); any Gck mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:121910 )

• ratio between plasma insulin and blood glucose level is significantly lower throughout the 120-minute period after glucose challenge

• insulin/glucose ratio in fasted, adults is significantly greater than in wild-type

abnormal insulin secretion ( J:121910 )

• mice are more sensitive to glucose and islets secret insulin in response to 2.5 mM glucose

hypoglycemia ( J:121910 )

• fasted 4-week old mice display mild hypoglycemia

decreased glucokinase activity ( J:121910 )

• glucokinase activity is reduced by 38% relative to wild-type

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:121910 )

N	• islets have similar morphology and total insulin content to wild-type islets when mice are fed a normal diet

abnormal insulin secretion ( J:121910 )

• mice are more sensitive to glucose and islets secret insulin in response to 2.5 mM glucose

Allelic Composition	Gck^tm3Mgn/Gck⁺
Genetic Background	B6.129S6-Gck^tm3Mgn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gck^tm3Mgn mutation (2 available); any Gck mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hypoglycemia ( J:121910 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hyperinsulinemic hypoglycemia		DOID:13317	OMIM:PS256450	J:121910

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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