Phenotypes associated with this allele

• Allele Symbol: Tg(APOE-Cyp7a1)1Road
• Allele Name: transgene insertion 1, Roger A Davis
• Allele ID: MGI:3701768
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(APOE-Cyp7a1)1Road/?	B6.Cg-Tg(APOE-Cyp7a1)1Road	MGI:5086272

Genotype
MGI:5086272

tg1

• Allelic Composition: Tg(APOE-Cyp7a1)1Road/?
• Genetic Background: B6.Cg-Tg(APOE-Cyp7a1)1Road

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:70134 )

• plasma contains less cholesterol in the HDL fractions than is found in controls

decreased circulating LDL cholesterol level ( J:70134 )

• APOB-containing lipoprotein (VLDL, intermediate density and LDL) fractions contain less cholesterol than is found in controls

decreased circulating VLDL cholesterol level ( J:70134 )

• APOB-containing lipoprotein (VLDL, intermediate density and LDL) fractions contain less cholesterol than is found in controls

increased bile salt level ( J:70134 )

• bile acid pool is 2-fold greater in transgenic mice

• relative content of the hydrophobic biliary bile acids is increased

• relative content of the hydrophilic biliary bile acids is decreased

increased triglyceride level ( J:70134 )

• significant increase in plasma triglyceride production and secretion following Triton WR-1339 (allows measurement of production of VLDL) administration as compared to increase in wild-type, however, concentration of triglycerides is not significantly increased in plasma

abnormal apolipoprotein level ( J:70134 )

• increase in production and secretion of APOB100 and APOB48, however, lipoproteins do not accumulate in plasma