Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ncf4tm1Pth targeted mutation 1, Phillip T Hawkins MGI:3701805 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• essentially all homozygous embryos fail in development before day 10
• however, 1 of 50 predicted homozygotes from heterozygous crosses was live-born
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• blood cell counts are normal and bone marrow derived neutrophils (BMNs) exhibit normal differentiated phenotypes with respect to morphology and phagocytosis of bacteria, zymosan and IgG-latex beads
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• in response to formyl-methionylleucylphenylalanine (fMLP), total accumuation of reactive oxygen species (ROS) is reduced by ~19% compared to Ncf4tm1Pth /+ heterozygotes
• intracellular ROS production in response to phagocytosis of IgG-latex beads is reduced by ~42% in primed compared to Ncf4tm1Pth /+ heterozygotes
• intracellular ROS production in response to S. aureus phagocytosis in primed BMN cells is reduced ~60% compared to Ncf4tm1Pth /+ heterozygotes
• initial phase of intracellular ROS formation in response to phorbyl myristate acetate (PMA) is reduced by almost half compared to heterozygous mice
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• mice have significant defect in ability to clear a S. aureus infection in vivo
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• in response to formyl-methionylleucylphenylalanine (fMLP), total accumuation of reactive oxygen species (ROS) is reduced by ~19% compared to Ncf4tm1Pth /+ heterozygotes
• intracellular ROS production in response to phagocytosis of IgG-latex beads is reduced by ~42% in primed compared to Ncf4tm1Pth /+ heterozygotes
• intracellular ROS production in response to S. aureus phagocytosis in primed BMN cells is reduced ~60% compared to Ncf4tm1Pth /+ heterozygotes
• initial phase of intracellular ROS formation in response to phorbyl myristate acetate (PMA) is reduced by almost half compared to heterozygous mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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