mortality/aging
• by E10.5, no homozygous embryos are detected
• homozygous embryos appear normal at E6.5, in size and number
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embryo
• at E8.5, ~25% of embryos are growth retarded
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• at E8.5, ~25% of embryos show severe developmental defects
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growth/size/body
• at E8.5, ~25% of embryos are growth retarded
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