Phenotypes associated with this allele

• Allele Symbol: Smad9^tm2.1Rob
• Allele Name: targeted mutation 2.1, Elizabeth J Robertson
• Allele ID: MGI:3701870
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smad9^tm2.1Rob/Smad9^tm2.1Rob	involves: 129S/SvEv	MGI:3702563
cx2	Smad1^tm1Rob/Smad1^+ Smad9^tm2.1Rob/Smad9^tm2.1Rob	involves: 129S/SvEv	MGI:3702567
cx3	Smad5^tm1Zuk/Smad5^+ Smad9^tm2.1Rob/Smad9^tm2.1Rob	involves: 129S/SvEv * 129S7/SvEvBrd	MGI:3702564
cx4	Smad1^tm1Rob/Smad1^+ Smad5^tm1Zuk/Smad5^+ Smad9^tm2.1Rob/Smad9^tm2.1Rob	involves: 129S/SvEv * 129S7/SvEvBrd	MGI:3702566

Genotype
MGI:3702563

hm1

• Allelic Composition: Smad9^tm2.1Rob/Smad9^tm2.1Rob
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:119296 )

• homozygous mice are healthy with no apparent abnormalities

Genotype
MGI:3702567

cx2

• Allelic Composition: Smad1^tm1Rob/Smad1⁺; Smad9^tm2.1Rob/Smad9^tm2.1Rob
• Genetic Background: involves: 129S/SvEv

mortality/aging

embryonic lethality during organogenesis ( J:119296 )

embryo

abnormal embryo development ( J:119296 )

abnormal embryonic tissue morphology ( J:119296 )

abnormal extraembryonic tissue morphology ( J:119296 )

growth/size/body

abnormal embryonic growth/weight/body size ( J:119296 )

cardiovascular system

abnormal heart development ( J:119296 )

nervous system

abnormal nervous system development ( J:119296 )

Genotype
MGI:3702564

cx3

• Allelic Composition: Smad5^tm1Zuk/Smad5⁺; Smad9^tm2.1Rob/Smad9^tm2.1Rob
• Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:119296 )

• authors state phenotype is same as previously described for Smad5 null embryos; Smad9 deficiency does not exacerbate the Smad5 phenotype

embryo

abnormal embryo development ( J:119296 )

abnormal extraembryonic tissue morphology ( J:119296 )

growth/size/body

abnormal embryonic growth/weight/body size ( J:119296 )

cardiovascular system

abnormal blood vessel morphology ( J:119296 )

abnormal heart development ( J:119296 )

nervous system

abnormal nervous system development ( J:119296 )

craniofacial

abnormal craniofacial development ( J:119296 )

reproductive system

abnormal germ cell morphology ( J:119296 )

cellular

abnormal germ cell morphology ( J:119296 )

Genotype
MGI:3702566

cx4

• Allelic Composition: Smad1^tm1Rob/Smad1⁺; Smad5^tm1Zuk/Smad5⁺; Smad9^tm2.1Rob/Smad9^tm2.1Rob
• Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

mortality/aging

prenatal lethality, complete penetrance ( J:119296 )

• no live born mice are obtained