Phenotypes associated with this allele

• Allele Symbol: Kmt2a^{tm1.1(Sh3gl1)Lcc}
• Allele Name: targeted mutation 1.1, Li Chong Chan
• Allele ID: MGI:3701943
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Kmt2a^tm1.1(Sh3gl1)Lcc/Kmt2a^+	involves: 129S/SvEv * C57BL/6	MGI:5559576
cn2	Kmt2a^tm1.1(Sh3gl1)Lcc/Kmt2a^+ Lyz2^tm1(cre)Ifo/Lyz2^+	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	MGI:5559577

Genotype
MGI:5559576

ht1

• Allelic Composition: Kmt2a^{tm1.1(Sh3gl1)Lcc}/Kmt2a⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:205605 )

• mice exhibit normal survival and phenotype

Genotype
MGI:5559577

cn2

• Allelic Composition: Kmt2a^{tm1.1(Sh3gl1)Lcc}/Kmt2a⁺; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

mortality/aging

premature death ( J:205605 )

• 50% survival at 6 months

immune system

enlarged spleen ( J:205605 )

• in some mice

myeloid hyperplasia ( J:205605 )

• increased immature myeloid cell population in the bone marrow, spleen and liver

enlarged lymph nodes ( J:205605 )

• in some mice

neoplasm

increased leukemia incidence ( J:205605 )

• acute myeloid leukemia after 12 months in some mice

• however, suppression of Prmt1 reduces leukemic cells

liver/biliary system

enlarged liver ( J:205605 )

• in some mice

hematopoietic system

enlarged spleen ( J:205605 )

• in some mice

myeloid hyperplasia ( J:205605 )

• increased immature myeloid cell population in the bone marrow, spleen and liver

growth/size/body

enlarged liver ( J:205605 )

• in some mice

enlarged spleen ( J:205605 )

• in some mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
leukemia		DOID:1240		J:205605