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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox1tm2Vep
targeted mutation 2, Vasso Episkopou
MGI:3701963
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sox1tm2Vep/Sox1tm2Vep Not Specified MGI:3702612
ht2
 		Sox1tm1Vep/Sox1tm2Vep involves: 129S/SvEv MGI:3702614
cx3
 		Sox1tm1Vep/Sox1tm2Vep
Sox2tm1Vep/Sox2+ 		involves: 129S/SvEv MGI:3702615
cx4
 		Enpp2tm1.1Vart/Enpp2tm1.1Vart
Sox1tm2Vep/Sox1+ 		involves: C57BL/6 MGI:4441464


Genotype
MGI:3702612
hm1
Allelic
Composition		 Sox1tm2Vep/Sox1tm2Vep
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox1tm2Vep mutation (0 available); any Sox1 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:99610 )
• homozygotes show same phenotype as Sox1tm1Vep homozygotes

behavior/neurological

nervous system

vision/eye




Genotype
MGI:3702614
ht2
Allelic
Composition		 Sox1tm1Vep/Sox1tm2Vep
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox1tm1Vep mutation (0 available); any Sox1 mutation (13 available)
Sox1tm2Vep mutation (0 available); any Sox1 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:99610 )
N
• generation and patterning of lateral ganglionic eminence (LGE) precursors is normal in mutants
abnormal neuronal migration ( J:99610 )
• early- and late-born neurons fail to migrate to appropriate positions to form ventral striatum
abnormal striatum morphology ( J:99610 )
• between E13 and 16, striatal mantle is more densely populated by proliferating precursors compared to wild-type
abnormal ventral striatum morphology ( J:99610 )
• migration or differentiation of ventral striatum (VS) neurons is disturbed in mutants
• at E13 to birth, the striatal bridges are absent
abnormal nucleus accumbens morphology ( J:99610 )
• staining for the markers Brn5 and Robo at E13 reveals a neural differentiation defect restricted in the region of the nucleus accumbens and olfactory tubercle (OT), and not the rest of the striatum
abnormal olfactory cortex morphology ( J:99610 )
• at E13 to birth, the striatal bridges and the olfactory tubercule (OT) layers are absent

cellular
abnormal neuronal migration ( J:99610 )
• early- and late-born neurons fail to migrate to appropriate positions to form ventral striatum




Genotype
MGI:3702615
cx3
Allelic
Composition		 Sox1tm1Vep/Sox1tm2Vep
Sox2tm1Vep/Sox2+
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox1tm1Vep mutation (0 available); any Sox1 mutation (13 available)
Sox1tm2Vep mutation (0 available); any Sox1 mutation (13 available)
Sox2tm1Vep mutation (0 available); any Sox2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:99610 )
• lethality associated with seizures is observed around weaning and is increased relative to Sox1-null mice

behavior/neurological

nervous system
abnormal olfactory cortex morphology ( J:99610 )
• embryos do not develop the olfactory tubercle (OT)
• at P10, OT neurons are detected in striatal mantle, but not in ventral striatum

vision/eye
microphthalmia ( J:99610 )
• mice are born with small eyes




Genotype
MGI:4441464
cx4
Allelic
Composition		 Enpp2tm1.1Vart/Enpp2tm1.1Vart
Sox1tm2Vep/Sox1+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Enpp2tm1.1Vart mutation (1 available); any Enpp2 mutation (79 available)
Sox1tm2Vep mutation (0 available); any Sox1 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal neural tube morphology ( J:159118 )
• at E9.5, head folds are asymmetric unlike in wild-type mice
open neural tube ( J:159118 )
• at E9.5
kinked neural tube ( J:159118 )
• at E9.5

nervous system
abnormal neural tube morphology ( J:159118 )
• at E9.5, head folds are asymmetric unlike in wild-type mice
open neural tube ( J:159118 )
• at E9.5
kinked neural tube ( J:159118 )
• at E9.5




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory