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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox2tm1Vep
targeted mutation 1, Vasso Episkopou
MGI:3701964
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Sox2tm1Vep/Sox2+ Not Specified MGI:3702611
cx2
 		Sox1tm1Vep/Sox1tm2Vep
Sox2tm1Vep/Sox2+ 		involves: 129S/SvEv MGI:3702615
cx3
 		Sox1tm1Vep/Sox1tm1Vep
Sox2tm1Vep/Sox2+ 		involves: 129S/SvEv MGI:3702617


Genotype
MGI:3702611
ht1
Allelic
Composition		 Sox2tm1Vep/Sox2+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2tm1Vep mutation (0 available); any Sox2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:99610 )
• mice are viable and fertile, with no phenotypic abnormalities; overexpression of Sox1 does not cause any abnormalities




Genotype
MGI:3702615
cx2
Allelic
Composition		 Sox1tm1Vep/Sox1tm2Vep
Sox2tm1Vep/Sox2+
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox1tm1Vep mutation (0 available); any Sox1 mutation (13 available)
Sox1tm2Vep mutation (0 available); any Sox1 mutation (13 available)
Sox2tm1Vep mutation (0 available); any Sox2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:99610 )
• lethality associated with seizures is observed around weaning and is increased relative to Sox1-null mice

behavior/neurological

nervous system
abnormal olfactory cortex morphology ( J:99610 )
• embryos do not develop the olfactory tubercle (OT)
• at P10, OT neurons are detected in striatal mantle, but not in ventral striatum

vision/eye
microphthalmia ( J:99610 )
• mice are born with small eyes




Genotype
MGI:3702617
cx3
Allelic
Composition		 Sox1tm1Vep/Sox1tm1Vep
Sox2tm1Vep/Sox2+
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox1tm1Vep mutation (0 available); any Sox1 mutation (13 available)
Sox2tm1Vep mutation (0 available); any Sox2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory cortex morphology ( J:99610 )
• olfactory tubercle (OT) region is compacted in absence of many Sox1 neurons
• neurons expressing Sox1 from the Sox2 locus migrate to the OT in absence of endogenous Sox1 expression; striatal bridges form




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory