All Phenotypes Sox2<tm1.1Vep> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sox2^tm1.1Vep
targeted mutation 1.1, Vasso Episkopou
MGI:3701965

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Sox2^tm1.1Vep/Sox2⁺	Not Specified	MGI:3702610
ht2	Sox2^tm1.1Vep/Sox2^tm1.2Vlcg	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac	MGI:5464914
cx3	Pax6^Sey-Neu/Pax6⁺ Sox2^tm1.1Vep/Sox2⁺	involves: 102 * C3H * C3H/HeN	MGI:3771033
cx4	Pou2f1^tm1Shrp/Pou2f1^tm1Shrp Sox2^tm1.1Vep/Sox2⁺	involves: 129S4/SvJae * C3H/HeN * C57BL/6	MGI:6159075
cx5	Pou2f1^tm1Shrp/Pou2f1⁺ Sox2^tm1.1Vep/Sox2⁺	involves: 129S4/SvJae * C3H/HeN * C57BL/6	MGI:6159076

Allelic Composition	Sox2^tm1.1Vep/Sox2⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2^tm1.1Vep mutation (0 available); any Sox2 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:99610 )

• mice are viable and fertile, with no phenotypic abnormalities

Allelic Composition	Sox2^tm1.1Vep/Sox2^tm1.2Vlcg
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2^tm1.1Vep mutation (0 available); any Sox2 mutation (56 available)
Sox2^tm1.2Vlcg mutation (0 available); any Sox2 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Sox2^tm1.2Vlcg/Sox2^tm1.2Vlcg and Sox2^tm1.1Vep/Sox2^tm1.2Vlcg embryos form disorganized extraembryonic tissues, but fail to form the epiblast, phenocopying Sox2^tm1.1Vep/Sox2^tm1.1Vep embryos

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:191980 )

• shortly after implantation

embryo

absent embryonic epiblast ( J:191980 )

• lack the epithelial cells typical of epiblast

absent egg cylinders ( J:191980 )

increased trophoblast giant cell number ( J:191980 )

Allelic Composition	Pax6^Sey-Neu/Pax6⁺ Sox2^tm1.1Vep/Sox2⁺
Genetic Background	involves: 102 * C3H * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Sey-Neu mutation (1 available); any Pax6 mutation (94 available)
Sox2^tm1.1Vep mutation (0 available); any Sox2 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal lens morphology ( J:119175 )

• at E11.5, lens dysmorphia is observed but is no more severe than in Pax6^Sey-Neu heterozygotes

Allelic Composition	Pou2f1^tm1Shrp/Pou2f1^tm1Shrp Sox2^tm1.1Vep/Sox2⁺
Genetic Background	involves: 129S4/SvJae * C3H/HeN * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou2f1^tm1Shrp mutation (1 available); any Pou2f1 mutation (99 available)
Sox2^tm1.1Vep mutation (0 available); any Sox2 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

absent nasal placodes ( J:119175 )

endocrine/exocrine glands

abnormal adenohypophysis morphology ( J:119175 )

• mice show dysmorphology of the adenohypophysis

abnormal pituitary diverticulum morphology ( J:119175 )

• dysmorphology is observed in some embryos

nervous system

abnormal adenohypophysis morphology ( J:119175 )

• mice show dysmorphology of the adenohypophysis

abnormal pituitary diverticulum morphology ( J:119175 )

• dysmorphology is observed in some embryos

respiratory system

absent nasal placodes ( J:119175 )

taste/olfaction

absent nasal placodes ( J:119175 )

vision/eye

abnormal lens morphology ( J:119175 )

• at E12.5, lenses are dysmorphic or absent

• peri-ocular region in severely affected animals resembles Pax6^Sey homozygous mice while mildly affected mutants show a similar phenotype to Pax6^Sey heterozygous mice

abnormal eye development ( J:119175 )

• ocular region is not evident at E10.5; ocular region resembles that seen in Pax6^Sey

abnormal lens induction ( J:119175 )

• lens placode induction shows severe defects

microphthalmia ( J:119175 )

• embryos generally exhibit microphthalmia in one eye and anophthalmia in the other

anophthalmia ( J:119175 )

• embryos generally exhibit anophthalmia in one eye and microphthalmia in the other

Allelic Composition	Pou2f1^tm1Shrp/Pou2f1⁺ Sox2^tm1.1Vep/Sox2⁺
Genetic Background	involves: 129S4/SvJae * C3H/HeN * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal lens morphology ( J:119175 )

• lens dysmorphology due to reduced Pax6 dosage; degree of dysmorphology is not exacerbated by reduction of Sox2 dosage

• at E12.5, lenses are normal

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