Phenotypes associated with this allele

• Allele Symbol: Lamtor2^tm1.1Lah
• Allele Name: targeted mutation 1.1, Lukas A Huber
• Allele ID: MGI:3701993
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lamtor2^tm1.1Lah/Lamtor2^tm1.1Lah Meox2^tm1(cre)Sor/Meox2^+	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	MGI:3712297
cn2	Lamtor2^tm1.1Lah/Lamtor2^tm1.1Lah Tg(KRT5-cre)1Tak/0	involves: 129P2/OlaHsd * C3H * C57BL/6 * SJL	MGI:3712300

Genotype
MGI:3712297

cn1

• Allelic Composition: Lamtor2^tm1.1Lah/Lamtor2^tm1.1Lah; Meox2^tm1(cre)Sor/Meox2⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:119075 )

• with conditional deletion in the epiblast, no homozygous embryos are detected at E10.5

Genotype
MGI:3712300

cn2

• Allelic Composition: Lamtor2^tm1.1Lah/Lamtor2^tm1.1Lah; Tg(KRT5-cre)1Tak/0
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * SJL

mortality/aging

neonatal lethality, complete penetrance ( J:119075 )

• mutants are born alive but die shortly after birth

homeostasis/metabolism

impaired skin barrier function ( J:119075 )

• defect is fatal leading to rapid dehydration and neonatal death

cellular

decreased cell proliferation ( J:119075 )

• proliferation in epidermis is reduced with mitotic cells reduced to 50% of total; BrdU-labeled cells in epidermis are reduced by 54%, with labeled cells residing in the basal layer

integument

impaired skin barrier function ( J:119075 )

• defect is fatal leading to rapid dehydration and neonatal death

abnormal epidermal layer morphology ( J:119075 )

• epidermis consists of 4 or less layers with nucleated cells frequently found in the uppermost cell layer at E18.5

abnormal epidermis stratum corneum morphology ( J:119075 )

• cornified layer is not well defined at E18.5

abnormal epidermis stratum granulosum morphology ( J:119075 )

• granular layer is not well defined at E18.5

thin epidermis ( J:119075 )

• thinner than in heterozygotes

reddish skin ( J:119075 )

• mutant skin is erythemic at E18.5

abnormal skin condition ( J:119075 )

• at E18.5, mutant skin appears moist compared to heterozygous littermates