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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gsk3btm1Grc
targeted mutation 1, Gerald R Crabtree
MGI:3701999
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gsk3btm1Grc/Gsk3btm1Grc involves: 129S6/SvEvTac * CD-1 MGI:3702519
ht2
 		Gsk3btm1Grc/Gsk3b+ involves: 129S6/SvEvTac MGI:5471805
ht3
 		Gsk3btm1Grc/Gsk3btm1Jrw involves: 129 * 129S6/SvEvTac * CD-1 MGI:3702520
cx4
 		Gsk3atm1a(EUCOMM)Wtsi/Gsk3a+
Gsk3btm1Grc/Gsk3btm1Grc 		involves: 129S6/SvEvTac * C57BL/6N MGI:5476706
cx5
 		Gsk3atm1a(EUCOMM)Wtsi/Gsk3a+
Gsk3btm1Grc/Gsk3b+ 		involves: 129S6/SvEvTac * C57BL/6N MGI:5476707


Genotype
MGI:3702519
hm1
Allelic
Composition		 Gsk3btm1Grc/Gsk3btm1Grc
Genetic
Background		 involves: 129S6/SvEvTac * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3btm1Grc mutation (1 available); any Gsk3b mutation (113 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:119186 )
• phenotype is identical to Gsk3btm1Jrw homozygotes

craniofacial
palatal shelves fail to meet at midline ( J:119186 )
• at E16.5, palatal shelves have rotated but do not meet at the midline
cleft secondary palate ( J:119186 )
• complete cleft of the secondary palate
• treatment with rapamycin at E13.5 through E15.0 results in partial (1 of 9) or complete (5 of 9) rescue of palatogenesis

skeleton
xiphoid process foramen ( J:119186 )
• often there are holes in the xiphoid cartilage
split sternum ( J:119186 )
• sternal bars are frequently bifurcated and the appearance of ossification centers is delayed
• treatment with rapamycin at E15.5 through E17.0 results in partial (3 of 7) or complete (4 of 7) rescue of sternal fusion
abnormal sternum ossification ( J:119186 )
• delay in ossification of the sternum is more obvious at early stages but by E18.5 levels of ossification in the sternum are sometimes similar to wild-type controls although the ossification centers are often in abnormal locations
delayed bone ossification ( J:119186 )
• delayed ossification of the skull, ear bones, and cranial base
• delay in ossification of the sternum is more obvious at early stages but by E18.5 levels of ossification in the sternum are sometimes similar to wild-type controls

digestive/alimentary system
palatal shelves fail to meet at midline ( J:119186 )
• at E16.5, palatal shelves have rotated but do not meet at the midline
cleft secondary palate ( J:119186 )
• complete cleft of the secondary palate
• treatment with rapamycin at E13.5 through E15.0 results in partial (1 of 9) or complete (5 of 9) rescue of palatogenesis

growth/size/body
palatal shelves fail to meet at midline ( J:119186 )
• at E16.5, palatal shelves have rotated but do not meet at the midline
cleft secondary palate ( J:119186 )
• complete cleft of the secondary palate
• treatment with rapamycin at E13.5 through E15.0 results in partial (1 of 9) or complete (5 of 9) rescue of palatogenesis




Genotype
MGI:5471805
ht2
Allelic
Composition		 Gsk3btm1Grc/Gsk3b+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3btm1Grc mutation (1 available); any Gsk3b mutation (113 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased myocardial infarct size ( J:186597 )
• following 2 hours of ischemia and 24 hours of reperfusion
increased myocardial infarct size ( J:186597 )
• following 2 hours of ischemia without reperfusion

homeostasis/metabolism
decreased myocardial infarct size ( J:186597 )
• following 2 hours of ischemia and 24 hours of reperfusion
increased myocardial infarct size ( J:186597 )
• following 2 hours of ischemia without reperfusion




Genotype
MGI:3702520
ht3
Allelic
Composition		 Gsk3btm1Grc/Gsk3btm1Jrw
Genetic
Background		 involves: 129 * 129S6/SvEvTac * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3btm1Grc mutation (1 available); any Gsk3b mutation (113 available)
Gsk3btm1Jrw mutation (0 available); any Gsk3b mutation (113 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:119186 )
• phenotype is identical to Gsk3btm1Jrw homozygotes

craniofacial
palatal shelves fail to meet at midline ( J:119186 )
• at E16.5, palatal shelves have rotated but do not meet at the midline
cleft secondary palate ( J:119186 )
• complete cleft of the secondary palate

skeleton
xiphoid process foramen ( J:119186 )
• often there are holes in the xiphoid cartilage
split sternum ( J:119186 )
• sternal bars are frequently bifurcated and the appearance of ossification centers is delayed
abnormal sternum ossification ( J:119186 )
• delay in ossification of the sternum is more obvious at early stages but by E18.5 levels of ossification in the sternum are sometimes similar to wild-type controls although the ossification centers are often in abnormal locations
delayed bone ossification ( J:119186 )
• delayed ossification of the skull, ear bones, and cranial base
• delay in ossification of the sternum is more obvious at early stages but by E18.5 levels of ossification in the sternum are sometimes similar to wild-type controls

digestive/alimentary system
palatal shelves fail to meet at midline ( J:119186 )
• at E16.5, palatal shelves have rotated but do not meet at the midline
cleft secondary palate ( J:119186 )
• complete cleft of the secondary palate

growth/size/body
palatal shelves fail to meet at midline ( J:119186 )
• at E16.5, palatal shelves have rotated but do not meet at the midline
cleft secondary palate ( J:119186 )
• complete cleft of the secondary palate




Genotype
MGI:5476706
cx4
Allelic
Composition		 Gsk3atm1a(EUCOMM)Wtsi/Gsk3a+
Gsk3btm1Grc/Gsk3btm1Grc
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3atm1a(EUCOMM)Wtsi mutation (2 available); any Gsk3a mutation (18 available)
Gsk3btm1Grc mutation (1 available); any Gsk3b mutation (113 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:195008 )
• varied

digestive/alimentary system
cleft palate ( J:195008 )
• varied

growth/size/body
cleft palate ( J:195008 )
• varied




Genotype
MGI:5476707
cx5
Allelic
Composition		 Gsk3atm1a(EUCOMM)Wtsi/Gsk3a+
Gsk3btm1Grc/Gsk3b+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3atm1a(EUCOMM)Wtsi mutation (2 available); any Gsk3a mutation (18 available)
Gsk3btm1Grc mutation (1 available); any Gsk3b mutation (113 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:195008 )
• in 1 of 5 mice

digestive/alimentary system
cleft palate ( J:195008 )
• in 1 of 5 mice

growth/size/body
cleft palate ( J:195008 )
• in 1 of 5 mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory