Phenotypes associated with this allele

• Allele Symbol: Tg(Cd4-CD4)2362Litt
• Allele Name: transgene insertion 2362, Dan R Littman
• Allele ID: MGI:3702083
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cd4^tm1Litt/Cd4^tm1Litt Tg(Cd4-CD4)2362Litt/0	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:3800657
cx2	Tg(Cd4-CD4)2362Litt/0 Tg(HLA-DR2)#Lfug/0 Tg(TCROb.1A12)#Lfug/0	involves: C57BL/6 * DBA/2 * SJL	MGI:5429704
tg3	Tg(Cd4-CD4)2362Litt/0	involves: C57BL/6 * SJL	MGI:3800658

Genotype
MGI:3800657

cx1

• Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt; Tg(Cd4-CD4)2362Litt/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:50435 )

N • the human CD4 transgene rescues the phenotype associated with Cd4^tm1Litt homozygotes

Genotype
MGI:5429704

cx2

• Allelic Composition: Tg(Cd4-CD4)2362Litt/0; Tg(HLA-DR2)#Lfug/0; Tg(TCROb.1A12)#Lfug/0
• Genetic Background: involves: C57BL/6 * DBA/2 * SJL

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:134764 )

• some mice die due to advanced disease during the onset of disease following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

immune system

increased susceptibility to experimental autoimmune encephalomyelitis ( J:134764 )

• following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin 85-90% of mice develop disease

• onset, clinical manifestations and course of disease are highly variable

• some mice die due to advanced disease during the onset of disease others develop a relapsing-remitting disease after the first attack

CNS inflammation ( J:134764 )

• spinal inflammation following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:134764 )

• following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin mice show one or more behavioral abnormalities indicative of white matter defects

lethargy ( J:134764 )

• drowsy

impaired balance ( J:134764 )

impaired coordination ( J:134764 )

abnormal locomotor activation ( J:134764 )

• slow movement

abnormal locomotor coordination ( J:134764 )

• spasticity

abnormal gait ( J:134764 )

• staggering gait

forelimb paralysis ( J:134764 )

nervous system

CNS inflammation ( J:134764 )

• spinal inflammation following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple sclerosis		DOID:2377	OMIM:612594 OMIM:612595 OMIM:612596	J:134764

Genotype
MGI:3800658

tg3

• Allelic Composition: Tg(Cd4-CD4)2362Litt/0
• Genetic Background: involves: C57BL/6 * SJL

immune system

immune system phenotype ( J:50435 )

N • CD4 T cells express both the mouse and human CD4 without any adverse effects on phenotype