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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Idd4.3C57L
C57L
MGI:3702140
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Idd4.3C57L/Idd4.3C57L involves: C57L/J * NOD MGI:3702142


Genotype
MGI:3702142
hm1
Allelic
Composition		 Idd4.3C57L/Idd4.3C57L
Genetic
Background		 involves: C57L/J * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:118951 )
• increased STAT5 phosphorylation in unactivated macrophages
abnormal cytokine secretion ( J:118951 )
• decreased GM-CSF production in unactivated macrophages
increased susceptibility to autoimmune diabetes ( J:118951 )
• increased diabetes incidence (27%)

hematopoietic system
abnormal macrophage physiology ( J:118951 )
• increased STAT5 phosphorylation in unactivated macrophages




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory