Phenotypes associated with this allele

• Allele Symbol: Igh^tm1.1Hws
• Allele Name: targeted mutation 1.1, Harry W Schroeder
• Allele ID: MGI:3702187
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh^tm1.1Hws/Igh^tm1.1Hws	BALB/cJ-Igh^tm1.1Hws	MGI:3704889
hm2	Igh^tm1.1Hws/Igh^tm1.1Hws	involves: BALB/c	MGI:3822281

Genotype
MGI:3704889

hm1

• Allelic Composition: Igh^tm1.1Hws/Igh^tm1.1Hws
• Genetic Background: BALB/cJ-Igh^tm1.1Hws

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased immature B cell number ( J:119391 )

• 22% decrease in the number of fraction E immature B cells

• however, the number of IgM+ IgD+ fraction F B cells, the absolute number of transitional, marginal zone and follicular cells in the spleen, and absolute numbers of B1a, B1b and B2 cells in the peritoneal cavity are all equivalent to wild-type

increased late pro-B cell number ( J:119391 )

• 24% increase in the number of fraction B pro-B cells

decreased pre-B cell number ( J:119391 )

• 20% decrease in the number of fraction D late pre-B cells

• however, the number of fraction C early pre-B cells is equivalent

decreased immunoglobulin level ( J:119391 )

• Ig-lambda levels are about half that of wild-type littermates 7 days after challenge with DEX, a T-independent antigen

• however, in naive mice or mice challenged with a T-dependent antigen Ig levels are indistinguishable from wild-type littermates

decreased IgM level ( J:119391 )

• levels are about half that of wild-type littermates 7 days after challenge with DEX, a T-independent antigen

hematopoietic system

decreased immature B cell number ( J:119391 )

• 22% decrease in the number of fraction E immature B cells

• however, the number of IgM+ IgD+ fraction F B cells, the absolute number of transitional, marginal zone and follicular cells in the spleen, and absolute numbers of B1a, B1b and B2 cells in the peritoneal cavity are all equivalent to wild-type

increased late pro-B cell number ( J:119391 )

• 24% increase in the number of fraction B pro-B cells

decreased pre-B cell number ( J:119391 )

• 20% decrease in the number of fraction D late pre-B cells

• however, the number of fraction C early pre-B cells is equivalent

decreased immunoglobulin level ( J:119391 )

• Ig-lambda levels are about half that of wild-type littermates 7 days after challenge with DEX, a T-independent antigen

• however, in naive mice or mice challenged with a T-dependent antigen Ig levels are indistinguishable from wild-type littermates

decreased IgM level ( J:119391 )

• levels are about half that of wild-type littermates 7 days after challenge with DEX, a T-independent antigen

Genotype
MGI:3822281

hm2

• Allelic Composition: Igh^tm1.1Hws/Igh^tm1.1Hws
• Genetic Background: involves: BALB/c

immune system

decreased immature B cell number ( J:142069 )

• there is over a 20% decrease in the number of immature B cells (ie. fraction E cells) found in the bone marrow

increased early pro-B cell number ( J:142069 )

• there is a 20% increase in the number of early pro-B cells (i.e. fraction B cells) found in the bone marrow of mutant mice

decreased late pro-B cell number ( J:142069 )

• there is a 20% decrease in the number of late pro-B cells (i.e. fraction D cells) compared to controls

increased IgG3 level ( J:142069 )

• antigen specific IgG3 levels are increased by 16-fold over wild-type in response to immunization with a recombinant strain of Salmonella that elicits a T cell-dependent B cell response

increased IgM level ( J:142069 )

• antigen specific IgM levels are doubled in response to immunization with a recombinant strain of Salmonella that elicits a T cell-dependent B cell response

hematopoietic system

decreased immature B cell number ( J:142069 )

• there is over a 20% decrease in the number of immature B cells (ie. fraction E cells) found in the bone marrow

increased early pro-B cell number ( J:142069 )

• there is a 20% increase in the number of early pro-B cells (i.e. fraction B cells) found in the bone marrow of mutant mice

decreased late pro-B cell number ( J:142069 )

• there is a 20% decrease in the number of late pro-B cells (i.e. fraction D cells) compared to controls

increased IgG3 level ( J:142069 )

• antigen specific IgG3 levels are increased by 16-fold over wild-type in response to immunization with a recombinant strain of Salmonella that elicits a T cell-dependent B cell response

increased IgM level ( J:142069 )

• antigen specific IgM levels are doubled in response to immunization with a recombinant strain of Salmonella that elicits a T cell-dependent B cell response