Phenotypes associated with this allele

• Allele Symbol: Mesp2^{tm7(mespb)Ysa}
• Allele Name: targeted mutation 7, Yumiko Saga
• Allele ID: MGI:3702191
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mesp2^tm7(mespb)Ysa/Mesp2^tm7(mespb)Ysa	involves: C57BL/6 * CBA	MGI:3702280
ht2	Mesp2^tm1Ysa/Mesp2^tm7(mespb)Ysa	involves: C57BL/6 * CBA	MGI:3702281

Genotype
MGI:3702280

hm1

• Allelic Composition: Mesp2^{tm7(mespb)Ysa}/Mesp2^{tm7(mespb)Ysa}
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal somite development ( J:75945 )

• at E11.5 in embryonic tails, initial segmental borders form; however, segregation is incomplete and somitic cells remain between the newly formed somites

• maintenance of segmental borders is impaired

abnormal rostral-caudal patterning of the somites ( J:75945 )

• expression analysis indicates impaired formation of rostral-caudal polarity in the anterior presomitic mesoderm

• severity of impairment is less than in homozygous null mice

abnormal somite border morphology ( J:75945 )

• maintenance of segmental borders is impaired

skeleton

rib fusion ( J:75945 )

• fusion of both the ribs and vertebral column, although not as severe as in homozygous null mice

• fusions are more severe than in mice where the neo cassette has been removed by Cre-mediated recombination

vertebral fusion ( J:75945 )

• fusion of both the ribs and vertebral column, although not as severe as in homozygous null mice

• fusions are more severe than in mice where the neo cassette has been removed by Cre-mediated recombination

Genotype
MGI:3702281

ht2

• Allelic Composition: Mesp2^tm1Ysa/Mesp2^{tm7(mespb)Ysa}
• Genetic Background: involves: C57BL/6 * CBA

embryo

abnormal somite development ( J:75945 )

• at E11.5 in embryonic tails, initial segmental borders form; however, segregation is incomplete and somitic cells remain between the newly formed somites

• maintenance of segmental borders is impaired

• failure of segregation is most severe in these embryos compared to mice either homozygous for the knock-in allele or carrying one allele with the neo cassette removed

abnormal rostral-caudal patterning of the somites ( J:75945 )

• expression analysis indicates impaired formation of rostral-caudal polarity in the anterior presomitic mesoderm

• severity of impairment is less than in homozygous null mice

abnormal somite border morphology ( J:75945 )

• maintenance of segmental borders is impaired

skeleton

rib fusion ( J:75945 )

• fusion of both the ribs and vertebral column, although not as severe as in homozygous null mice

• fusions are more severe than in mice where the neo cassette has been removed by Cre-mediated recombination

vertebral fusion ( J:75945 )

• fusion of both the ribs and vertebral column, although not as severe as in homozygous null mice

• fusions are more severe than in mice where the neo cassette has been removed by Cre-mediated recombination