Phenotypes associated with this allele

• Allele Symbol: Tg(NEFL-cre)50Msd
• Allele Name: transgene insertion 50, Michael Sendtner
• Allele ID: MGI:3702327
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Stat3^tm1Aki/Stat3^tm2Aki Tg(NEFL-cre)50Msd/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1	MGI:4410454

Genotype
MGI:4410454

cn1

• Allelic Composition: Stat3^tm1Aki/Stat3^tm2Aki; Tg(NEFL-cre)50Msd/0
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal motor neuron morphology ( J:77229 )

• motor neurons require higher concentrations of CNTF than wild-type cells to survive in culture

• however, the number of facial and spinal neurons in mice is normal

abnormal neuron physiology ( J:77229 )

• motor neurons require higher concentrations of CNTF than wild-type cells to survive in culture

• however, the number of facial and spinal neurons in mice is normal

homeostasis/metabolism

increased susceptibility to injury ( J:77229 )

• after facial nerve transection, mice exhibit loss of facial motor neurons unlike in similarly treated wild-type mice

• however, treatment with BDNF or CNTF improves neuron survival after facial nerve transection