Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(CAG-cat,-Notch1)1Ysa transgene insertion 1, Yumiko Saga MGI:3702441 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• defects in heart morphology and development are unaffected by the presence of the transgene
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• defects in heart morphology and development are unaffected by the presence of the transgene
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants exhibit impaired ventricular trabeculation, however there is much less trabeculation of the atrioventricular myocardium compared with mutants that are not null for Hey1
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• mutants exhibit ectopic appearance of cell masses in the atrioventricular cushion
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• the interventricular septum is shifted to the right side
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• mutants exhibit impaired ventricular trabeculation, however there is much less trabeculation of the atrioventricular myocardium compared with mutants that are not null for Hey1
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• embryos do not develop beyond E10.5 and die before E11.5
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• exhibit impaired myocardium of the atrioventricular canal
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• cardiac myofibrils are poorly formed
• mutants exhibit impaired ventricular myocardial differentiation
• the atrioventricular myocardial wall shows evidence of trabeculation
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• exhibit ectopic appearance of cell masses in the atrioventricular cushion
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• hearts are deformed in shape with a rough surface morphology
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• exhibit abnormal accumulation of trabecular cells in the ventricular wall near the compact layer
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• the interventricular septum is shifted to the right side
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• the left ventricle is expanded
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• the right ventricle is reduced in size
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• exhibit impaired myocardium of the atrioventricular canal
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• cardiac myofibrils are poorly formed
• mutants exhibit impaired ventricular myocardial differentiation
• the atrioventricular myocardial wall shows evidence of trabeculation
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• exhibit abnormal accumulation of trabecular cells in the ventricular wall near the compact layer
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• cardiac myofibrils show an unclear sarcomere structure
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• trabecular layer defects observed in Pofut1tm1Ysa/Pofut1tm1Ysa Mesp1tm2(cre)Ysa/Mesp1+ mice are partially rescued
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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