About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lhx6tm1Vpa
targeted mutation1, Vassilis Pachnis
MGI:3702513
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lhx6tm1Vpa/Lhx6tm1Vpa involves: 129P2/OlaHsd * C57BL/6 MGI:5498871
ht2
Lhx6tm1Vpa/Lhx6tm2Vpa involves: 129P2/OlaHsd * C57BL/6 MGI:5498872


Genotype
MGI:5498871
hm1
Allelic
Composition
Lhx6tm1Vpa/Lhx6tm1Vpa
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx6tm1Vpa mutation (0 available); any Lhx6 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice survive to adulthood, are fertile and show no gross morphological abnormalities




Genotype
MGI:5498872
ht2
Allelic
Composition
Lhx6tm1Vpa/Lhx6tm2Vpa
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx6tm1Vpa mutation (0 available); any Lhx6 mutation (27 available)
Lhx6tm2Vpa mutation (0 available); any Lhx6 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit normal MGE-derived cortical interneurons and spontaneous inhibitory postsynaptic currents
• under mild stress
• interictal spikes in all mice
• after 4 weeks of age, mice exhibit histopathological evidence of seizures (NPY, EdU and Cr staining) with evidence of enhanced neurogenesis unlike Lhx6tm1Vpa heterozygotes
• mice exhibit reduced Pva+ interneurons in the dentate gyrus and widespread loss of Sst+ interneurons in the cortex (preceding onset of tonic-clonic seizures) compared with Lhx6tm1Vpa heterozygotes
• however, mice exhibit normal numbers of Pva+ interneurons is in the somatosensory cortex and the CA1 region of the hippocampus and a normal complement of MGE-derived cortical interneurons
• mice exhibit reduced Pva+ interneurons in the dentate gyrus and widespread loss of Sst+ interneurons in the cortex (preceding onset of tonic-clonic seizures) compared with Lhx6tm1Vpa heterozygotes
• however, mice exhibit normal numbers of Pva+ interneurons is in the somatosensory cortex and the CA1 region of the hippocampus and a normal complement of MGE-derived cortical interneurons
• 6-fold higher frequency of dendritic mIPSCs compared with Lhx6tm1Vpa heterozygotes

behavior/neurological
• under mild stress
• interictal spikes in all mice

cellular
• after 4 weeks of age, mice exhibit histopathological evidence of seizures (NPY, EdU and Cr staining) with evidence of enhanced neurogenesis unlike Lhx6tm1Vpa heterozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory