normal phenotype
• mice survive to adulthood, are fertile and show no gross morphological abnormalities
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Allele Symbol Allele Name Allele ID |
Lhx6tm1Vpa targeted mutation1, Vassilis Pachnis MGI:3702513 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice survive to adulthood, are fertile and show no gross morphological abnormalities
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice exhibit normal MGE-derived cortical interneurons and spontaneous inhibitory postsynaptic currents
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• in kainic acid treated mice
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• under mild stress
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• interictal spikes in all mice
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• after 4 weeks of age, mice exhibit histopathological evidence of seizures (NPY, EdU and Cr staining) with evidence of enhanced neurogenesis unlike Lhx6tm1Vpa heterozygotes
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• mice exhibit reduced Pva+ interneurons in the dentate gyrus and widespread loss of Sst+ interneurons in the cortex (preceding onset of tonic-clonic seizures) compared with Lhx6tm1Vpa heterozygotes
• however, mice exhibit normal numbers of Pva+ interneurons is in the somatosensory cortex and the CA1 region of the hippocampus and a normal complement of MGE-derived cortical interneurons
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• mice exhibit reduced Pva+ interneurons in the dentate gyrus and widespread loss of Sst+ interneurons in the cortex (preceding onset of tonic-clonic seizures) compared with Lhx6tm1Vpa heterozygotes
• however, mice exhibit normal numbers of Pva+ interneurons is in the somatosensory cortex and the CA1 region of the hippocampus and a normal complement of MGE-derived cortical interneurons
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• 6-fold higher frequency of dendritic mIPSCs compared with Lhx6tm1Vpa heterozygotes
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• in kainic acid treated mice
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• under mild stress
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• interictal spikes in all mice
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• after 4 weeks of age, mice exhibit histopathological evidence of seizures (NPY, EdU and Cr staining) with evidence of enhanced neurogenesis unlike Lhx6tm1Vpa heterozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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