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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcrbtm1Slek
targeted mutation 1, Barry P Sleckman
MGI:3702573
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tcrbtm1Slek/Tcrbtm1Slek Not Specified MGI:3703049
ht2
 		Tcrbtm1Slek/Tcrbtm5Slek Not Specified MGI:3829444
ht3
 		Tcrbtm1Slek/Tcrbtm6Slek Not Specified MGI:3829447
ht4
 		Tcrbtm1(Tcrb)Chb/Tcrbtm1Slek Not Specified MGI:3843508


Genotype
MGI:3703049
hm1
Allelic
Composition		 Tcrbtm1Slek/Tcrbtm1Slek
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrbtm1Slek mutation (0 available); any Tcrb mutation (97 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:119552 )
N
• mice show normal thymocyte development and splenic T cell numbers




Genotype
MGI:3829444
ht2
Allelic
Composition		 Tcrbtm1Slek/Tcrbtm5Slek
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrbtm1Slek mutation (0 available); any Tcrb mutation (97 available)
Tcrbtm5Slek mutation (0 available); any Tcrb mutation (97 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell receptor beta chain V(D)J recombination ( J:143738 )
• the Tcrbtm1Slek allele is always rearranged in alphabeta T cells but the Tcrbtm5Slek allele is only rearranged in about half the T cells

hematopoietic system
abnormal T cell receptor beta chain V(D)J recombination ( J:143738 )
• the Tcrbtm1Slek allele is always rearranged in alphabeta T cells but the Tcrbtm5Slek allele is only rearranged in about half the T cells




Genotype
MGI:3829447
ht3
Allelic
Composition		 Tcrbtm1Slek/Tcrbtm6Slek
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrbtm1Slek mutation (0 available); any Tcrb mutation (97 available)
Tcrbtm6Slek mutation (0 available); any Tcrb mutation (97 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell receptor beta chain V(D)J recombination ( J:143738 )
• rearrangement of the V gene segments to the D gene segment on the Tcrbtm6Slek allele occurs at much reduced rate

hematopoietic system
abnormal T cell receptor beta chain V(D)J recombination ( J:143738 )
• rearrangement of the V gene segments to the D gene segment on the Tcrbtm6Slek allele occurs at much reduced rate




Genotype
MGI:3843508
ht4
Allelic
Composition		 Tcrbtm1(Tcrb)Chb/Tcrbtm1Slek
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrbtm1Slek mutation (0 available); any Tcrb mutation (97 available)
Tcrbtm1(Tcrb)Chb mutation (0 available); any Tcrb mutation (97 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell morphology ( J:147947 )
• there is a decreased percentage of alpha-beta T cells expressing T Cell receptors (TCR) that are partially encoded Vbeta5 or Vbeta8 gene segments
abnormal T cell receptor beta chain V(D)J recombination ( J:147947 )
• in T cells, complete VbetaDJbeta exon rearrangement occurs more frequently (69%) on the Tcrbtm1(Tcrb)Chb allele than on the Tcrbtm1Slek allele (31%)
• sequencing of T cell hybridomas suggest there is both an increase in rearrangements on the Tcrbtm1(Tcrb)Chb allele and a preferential selection of thymocytes with in-frame VbetaDJbeta rearrangements on this allele
abnormal double-negative T cell morphology ( J:147947 )
• the frequency of DN3 thymocytes is slightly decreased while the frequency of DN4 thymocytes is slightly increased
decreased CD8-positive, alpha-beta T cell number ( J:147947 )
• frequency of CD8+ T cells in the spleen is slightly decreased
increased single-positive T cell number ( J:147947 )
• there is an increased frequency of single-positive thymocytes (both CD4+ and CD8+)

hematopoietic system
abnormal T cell morphology ( J:147947 )
• there is a decreased percentage of alpha-beta T cells expressing T Cell receptors (TCR) that are partially encoded Vbeta5 or Vbeta8 gene segments
abnormal T cell receptor beta chain V(D)J recombination ( J:147947 )
• in T cells, complete VbetaDJbeta exon rearrangement occurs more frequently (69%) on the Tcrbtm1(Tcrb)Chb allele than on the Tcrbtm1Slek allele (31%)
• sequencing of T cell hybridomas suggest there is both an increase in rearrangements on the Tcrbtm1(Tcrb)Chb allele and a preferential selection of thymocytes with in-frame VbetaDJbeta rearrangements on this allele
abnormal double-negative T cell morphology ( J:147947 )
• the frequency of DN3 thymocytes is slightly decreased while the frequency of DN4 thymocytes is slightly increased
decreased CD8-positive, alpha-beta T cell number ( J:147947 )
• frequency of CD8+ T cells in the spleen is slightly decreased
increased single-positive T cell number ( J:147947 )
• there is an increased frequency of single-positive thymocytes (both CD4+ and CD8+)




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory