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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcrbtm2Slek
targeted mutation 2, Barry P Sleckman
MGI:3702574
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tcrbtm2Slek/Tcrbtm2Slek Not Specified MGI:3703050
cx2
 		Tcrbtm2Slek/Tcrbtm2Slek
Trbv13-2tm1(CD2)Zhu/Trbv13-2tm1(CD2)Zhu 		involves: 129 * C57BL/6 MGI:3711858


Genotype
MGI:3703050
hm1
Allelic
Composition		 Tcrbtm2Slek/Tcrbtm2Slek
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrbtm2Slek mutation (0 available); any Tcrb mutation (97 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested T cell differentiation ( J:119552 )
• development is blocked at the double negative (DN) stage
decreased T cell number ( J:119552 )
• mice have reduced numbers of peripheral T cells relative to wild-type

immune system
arrested T cell differentiation ( J:119552 )
• development is blocked at the double negative (DN) stage
decreased T cell number ( J:119552 )
• mice have reduced numbers of peripheral T cells relative to wild-type




Genotype
MGI:3711858
cx2
Allelic
Composition		 Tcrbtm2Slek/Tcrbtm2Slek
Trbv13-2tm1(CD2)Zhu/Trbv13-2tm1(CD2)Zhu
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrbtm2Slek mutation (0 available); any Tcrb mutation (97 available)
Trbv13-2tm1(CD2)Zhu mutation (0 available); any Trbv13-2 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell differentiation ( J:121608 )
• human CD2 expression (germline transcription from the Vbeta8.2 promoter) is higher in cells expressing Vbeta genes downstream of Vbeta8.2 promoter, whereas no CD2 expression is detected from T cells using V genes upstream of Vbeta8.2

immune system
abnormal T cell differentiation ( J:121608 )
• human CD2 expression (germline transcription from the Vbeta8.2 promoter) is higher in cells expressing Vbeta genes downstream of Vbeta8.2 promoter, whereas no CD2 expression is detected from T cells using V genes upstream of Vbeta8.2




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory