Phenotypes associated with this allele

• Allele Symbol: Hoxa1^tm5Mrc
• Allele Name: targeted mutation 5, Mario R Capecchi
• Allele ID: MGI:3702593
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Hoxa1^tm5Mrc/Hoxa1^+ Hoxb1^tm5Mrc/Hoxb1^tm5Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3703018
cx2	Hoxa1^tm5Mrc/Hoxa1^tm5Mrc Hoxb1^tm5Mrc/Hoxb1^tm5Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3703022

Genotype
MGI:3703018

cx1

• Allelic Composition: Hoxa1^tm5Mrc/Hoxa1⁺; Hoxb1^tm5Mrc/Hoxb1^tm5Mrc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal reflex ( J:119279 )

• 17% of mice have a noticeably narrower range of whisker movements on one side

• 8% have a mutant-like eyelid closure reflex in one eye

paralysis ( J:119279 )

• some facial motor hypomorphism is observed; Hoxa1 haploinsufficiency is observed

nervous system

small facial motor nucleus ( J:119279 )

• haploinsufficient presumptive facial nuclei are smaller, rounder, and located more internally than wild-type

abnormal facial nerve morphology ( J:119279 )

• zygomatic and temporal branches of facial nerve in affected mutants are thinner and sometimes atypically formed, but rarely missing

Genotype
MGI:3703022

cx2

• Allelic Composition: Hoxa1^tm5Mrc/Hoxa1^tm5Mrc; Hoxb1^tm5Mrc/Hoxb1^tm5Mrc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

nervous system

nervous system phenotype ( J:119279 )

N • facial motor nuclei are not markedly different from wild-type