Phenotypes associated with this allele

• Allele Symbol: Hoxb1^{tm8(Hoxa1)Mrc}
• Allele Name: targeted mutation 8, Mario R Capecchi
• Allele ID: MGI:3702595
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxb1^tm8(Hoxa1)Mrc/Hoxb1^tm8(Hoxa1)Mrc	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:3703017
ht2	Hoxb1^tm5Mrc/Hoxb1^tm8(Hoxa1)Mrc	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:3703020
cx3	Hoxa1^tm3.1Mrc/Hoxa1^tm4(Hoxb1)Mrc Hoxb1^tm5Mrc/Hoxb1^tm8(Hoxa1)Mrc	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:3703012
cx4	Hoxa1^tm4(Hoxb1)Mrc/Hoxa1^tm4(Hoxb1)Mrc Hoxb1^tm5Mrc/Hoxb1^tm8(Hoxa1)Mrc	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:3703016
cx5	Hoxa1^tm4(Hoxb1)Mrc/Hoxa1^tm4(Hoxb1)Mrc Hoxb1^tm8(Hoxa1)Mrc/Hoxb1^tm8(Hoxa1)Mrc	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:3703026

Genotype
MGI:3703017

hm1

• Allelic Composition: Hoxb1^{tm8(Hoxa1)Mrc}/Hoxb1^{tm8(Hoxa1)Mrc}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:119279 )

• only 12% of progeny are homozygous, while 58% are heterozygous and 30% are wild-type, in contrast to expected 25:50:25 ratio

Genotype
MGI:3703020

ht2

• Allelic Composition: Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:119279 )

• mutants are indistinguishable from wild-type

Genotype
MGI:3703012

cx3

• Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^{tm4(Hoxb1)Mrc}; Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

behavior/neurological

abnormal blinking ( J:119279 )

• facial paralysis is predominantly manifested in impaired eyeblink reflex

facial paralysis ( J:119279 )

• majority of mice show various levels of facial paralysis

Genotype
MGI:3703016

cx4

• Allelic Composition: Hoxa1^{tm4(Hoxb1)Mrc}/Hoxa1^{tm4(Hoxb1)Mrc}; Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

behavior/neurological

abnormal reflex ( J:119279 )

• eyeblink reflex is impaired in 58% of mutants; only 11% are considered to be severely affected

nervous system

abnormal facial nerve morphology ( J:119279 )

• zygomatic and temporal branches of facial nerve have normal caliber, but occasionally show atypical arborization pattern

Genotype
MGI:3703026

cx5

• Allelic Composition: Hoxa1^{tm4(Hoxb1)Mrc}/Hoxa1^{tm4(Hoxb1)Mrc}; Hoxb1^{tm8(Hoxa1)Mrc}/Hoxb1^{tm8(Hoxa1)Mrc}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:119279 )

• mice do not show facial paralysis or behavioral abnormalities