About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Procrtm2Cte
targeted mutation 2, Charles T Esmon
MGI:3702857
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Meox2tm1(cre)Sor/Meox2+
Procrtm2Cte/Procrtm2Cte 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6 MGI:3702949
cn2
 		Meox2tm1(cre)Sor/Meox2+
Procrtm1Cte/Procrtm2Cte 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6 MGI:3702950
cn3
 		Procrtm2Cte/Procrtm3Cte
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 MGI:3831370


Genotype
MGI:3702949
cn1
Allelic
Composition		 Meox2tm1(cre)Sor/Meox2+
Procrtm2Cte/Procrtm2Cte
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Procrtm2Cte mutation (0 available); any Procr mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal hematopoietic system morphology/development ( J:119529 )
• mutants have slightly increased thrombin-antithrombin (TAT) complex levels
thrombocytopenia ( J:119529 )
• 2-month old mice show decreased platelet counts compared to wild-type; differences increase and become significant with age

homeostasis/metabolism
increased circulating C-reactive protein level ( J:119529 )
• circulating levels are higher in 2 month old mutants
• however, after thrombin infusion, circulating APC (activated protein C) levels are only 5.2% that of wild-type controls
decreased circulating fibrinogen level ( J:119529 )
• fibrinogen levels are decreased relative to wild-type; differences increase and become significant with age

immune system
increased circulating C-reactive protein level ( J:119529 )
• circulating levels are higher in 2 month old mutants
• however, after thrombin infusion, circulating APC (activated protein C) levels are only 5.2% that of wild-type controls
decreased circulating fibrinogen level ( J:119529 )
• fibrinogen levels are decreased relative to wild-type; differences increase and become significant with age




Genotype
MGI:3702950
cn2
Allelic
Composition		 Meox2tm1(cre)Sor/Meox2+
Procrtm1Cte/Procrtm2Cte
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Procrtm1Cte mutation (0 available); any Procr mutation (17 available)
Procrtm2Cte mutation (0 available); any Procr mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:119529 )
• no Procr-null, Meox2 heterozygous mice are obtained




Genotype
MGI:3831370
cn3
Allelic
Composition		 Procrtm2Cte/Procrtm3Cte
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Procrtm2Cte mutation (0 available); any Procr mutation (17 available)
Procrtm3Cte mutation (0 available); any Procr mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:144388 )
N
• mice were born in the expected ratio




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory