hematopoietic system
• mutants have slightly increased thrombin-antithrombin (TAT) complex levels
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• 2-month old mice show decreased platelet counts compared to wild-type; differences increase and become significant with age
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homeostasis/metabolism
• circulating levels are higher in 2 month old mutants
• however, after thrombin infusion, circulating APC (activated protein C) levels are only 5.2% that of wild-type controls
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• fibrinogen levels are decreased relative to wild-type; differences increase and become significant with age
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immune system
• circulating levels are higher in 2 month old mutants
• however, after thrombin infusion, circulating APC (activated protein C) levels are only 5.2% that of wild-type controls
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• fibrinogen levels are decreased relative to wild-type; differences increase and become significant with age
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