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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Procrtm2Cte
targeted mutation 2, Charles T Esmon
MGI:3702857
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Meox2tm1(cre)Sor/Meox2+
Procrtm2Cte/Procrtm2Cte 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6 MGI:3702949
cn2
 		Meox2tm1(cre)Sor/Meox2+
Procrtm1Cte/Procrtm2Cte 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6 MGI:3702950
cn3
 		Procrtm2Cte/Procrtm3Cte
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 MGI:3831370


Genotype
MGI:3702949
cn1
Allelic
Composition		 Meox2tm1(cre)Sor/Meox2+
Procrtm2Cte/Procrtm2Cte
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Procrtm2Cte mutation (0 available); any Procr mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal hematopoietic system morphology/development ( J:119529 )
• mutants have slightly increased thrombin-antithrombin (TAT) complex levels
thrombocytopenia ( J:119529 )
• 2-month old mice show decreased platelet counts compared to wild-type; differences increase and become significant with age

homeostasis/metabolism
increased circulating C-reactive protein level ( J:119529 )
• circulating levels are higher in 2 month old mutants
• however, after thrombin infusion, circulating APC (activated protein C) levels are only 5.2% that of wild-type controls
decreased circulating fibrinogen level ( J:119529 )
• fibrinogen levels are decreased relative to wild-type; differences increase and become significant with age

immune system
increased circulating C-reactive protein level ( J:119529 )
• circulating levels are higher in 2 month old mutants
• however, after thrombin infusion, circulating APC (activated protein C) levels are only 5.2% that of wild-type controls
decreased circulating fibrinogen level ( J:119529 )
• fibrinogen levels are decreased relative to wild-type; differences increase and become significant with age




Genotype
MGI:3702950
cn2
Allelic
Composition		 Meox2tm1(cre)Sor/Meox2+
Procrtm1Cte/Procrtm2Cte
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Procrtm1Cte mutation (0 available); any Procr mutation (15 available)
Procrtm2Cte mutation (0 available); any Procr mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:119529 )
• no Procr-null, Meox2 heterozygous mice are obtained




Genotype
MGI:3831370
cn3
Allelic
Composition		 Procrtm2Cte/Procrtm3Cte
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Procrtm2Cte mutation (0 available); any Procr mutation (15 available)
Procrtm3Cte mutation (0 available); any Procr mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:144388 )
N
• mice were born in the expected ratio




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory