Analysis Tools
reproductive system
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• mice are fertile
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behavior/neurological
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• mice have reductions in line crossing behavior, total distance traveled, mean velocity, rearing, mean distance to wall, and number of holes explored in a Hole Board Test
• however, turns, turn angle, angular velocity, meander, maximum duration on board, board entry, group contact, immobility, defecation, and grooming behaviors were all normal
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• mice exhibit a reduced mean latency period on a rotarod despite improved performances during consecutive trials
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• at 18 weeks, males have reduced forelimb grip strength of 72.2+/-3.37 compared to 85.85+/-4.19 ponds in wild-type
• however, mice have normal basic movement and reflexes as determined by SHIRPA parameters
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• decrease in rearing
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