Phenotypes associated with this allele

• Allele Symbol: Nfkbid^tm1Ktak
• Allele Name: targeted mutation 1, Kiyoshi Takeda
• Allele ID: MGI:3702939
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nfkbid^tm1Ktak/Nfkbid^tm1Ktak	involves: 129P2/OlaHsd * C57BL/6	MGI:3712232

Genotype
MGI:3712232

hm1

• Allelic Composition: Nfkbid^tm1Ktak/Nfkbid^tm1Ktak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to induced colitis ( J:113334 )

• mice are more susceptible to DSS-induced colitis and produce more IFN-gamma in response

increased interferon-gamma secretion ( J:113334 )

• produce more IFN-gamma in response to DSS-induced colitis

increased interleukin-12 secretion ( J:113334 )

• dendritic cells produce more IL-12p70 in response to LPS stimulation

increased interleukin-12b secretion ( J:113334 )

• dendritic cells produce more IL-12p40 in response to LPS stimulation

• macrophages stimulated with LSP produce more IL-12p40

increased interleukin-6 secretion ( J:113334 )

• LPS stimulation of peritoneal macrophages and marrow-derived dendritic cells results in increased IL-6 production compared to normal

• in response to treatment with several TLR ligands (mycoplasmal lipopeptides, Pam₂CSK₄, peptidoglycan and imiquimod) IL-6 but not TNF-alpha production is increased

increased susceptibility to endotoxin shock ( J:113334 )

• mice are more susceptible to lethality associated with LPS-induced endotoxin shock and die by 4 days post-exposure

digestive/alimentary system

increased susceptibility to induced colitis ( J:113334 )

• mice are more susceptible to DSS-induced colitis and produce more IFN-gamma in response