Analysis Tools
growth/size/body
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• at 1 and 3 months of age, males weigh 10-15% less than control C57BL/6 or 129/Sv males
• Background Sensitivity: female body weight is reduced by ~10% compared to C57BL/6 controls, but is similar to 129/Sv controls
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homeostasis/metabolism
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• levels are 2.3- to 3.8-fold higher compared to control C57BL/6 or 129/Sv females
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• levels are 3.8- to 6.7-fold higher compared to control C57BL/6 or 129/Sv females
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• plasma total cholesterol levels in 4-month old males are 49% lower than in control C57BL/6 and 25% lower than in control 129/Sv males
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• mice show 74-95% decrease in NADPH-cytochrome P450 reductase protein compared to wild-type; largest reductions are seen in female brain at all ages and in male and female lungs at 90 days of age
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• mice show decreased ability to clear pentobarbital
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reproductive system
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• females are inferile, as shown by breeding of female homozygotes with wild-type males; only 4/9 females showed sperm plugs and produced no pups
• in another experiment, 5/12 females showed sperm plugs, with only 3 females becoming pregnant and producing a total of 8 pups
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liver/biliary system
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• mild centrolobular lipidosis is detected in some homozygotes between 2-4 months of age
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renal/urinary system
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• kidney weight in males is reduced by ~30% compared to controls
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cardiovascular system
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• at 3 months of age, male heart weight is reduced by ~30% compared to controls
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