Phenotypes associated with this allele

• Allele Symbol: Helt^tm1Wrst
• Allele Name: targeted mutation 1, Wolfgang Wurst
• Allele ID: MGI:3703237
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Helt^tm1Wrst/Helt^tm1Wrst	B6.Cg-Helt^tm1Wrst	MGI:3703901

Genotype
MGI:3703901

hm1

• Allelic Composition: Helt^tm1Wrst/Helt^tm1Wrst
• Genetic Background: B6.Cg-Helt^tm1Wrst

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:119562 )

• no mice survive beyond 5 weeks

postnatal lethality, incomplete penetrance ( J:119562 )

• some deaths occur in second week after birth; more mice die in weeks 3 and 4

growth/size/body

decreased body weight ( J:119562 )

• 3-4 weeks after birth, body weight of survivors is one third that of wild-type littermates, due to inability to nurse

postnatal growth retardation ( J:119562 )

• during second week, homozygotes display gradual growth reduction

nervous system

nervous system phenotype ( J:119562 )

N • non-GABAergic systems show no obvious abnormalities compared to wild-type; also, other midbrain regions do not show any morphological changes

seizures ( J:119562 )

• occasional convulsions in mice over 14 days of age are observed

tonic-clonic seizures ( J:119562 )

• mice display tonic-clonic spasms with hyperextended hindlimb episodes during convulsions

loss of GABAergic neurons ( J:119562 )

• complete loss of Gad65 and Gad67 expression is observed in mutants; this is seen in the most rostral and most caudal region of the inferior colliculus

behavior/neurological

abnormal suckling behavior ( J:119562 )

• pups show decreased body weight resulting from their inability to nurse properly

limb grasping ( J:119562 )

• all homozygotes retract their fore/hindlimbs and digits (limb clenching) when lifted by the tail

seizures ( J:119562 )

• occasional convulsions in mice over 14 days of age are observed

tonic-clonic seizures ( J:119562 )

• mice display tonic-clonic spasms with hyperextended hindlimb episodes during convulsions