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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rictortm1.1Mgn
targeted mutation 1.1, Mark A Magnuson
MGI:3703321
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ptentm1Hwu/Ptentm1Hwu
Rictortm1.1Mgn/Rictortm1.1Mgn 		involves: 129S4/SvJae * 129S6/SvEvTac MGI:4848147
cn2
 		Ptentm1Hwu/Ptentm1Hwu
Rictortm1.1Mgn/Rictortm1.1Mgn
Tg(Ins2-cre)25Mgn/0 		involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * DBA MGI:5008147
cn3
 		Rictortm1.1Mgn/Rictortm1.2Mgn
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL MGI:3706134
cn4
 		Rictortm1.1Mgn/Rictortm1.1Mgn
Tg(Ins2-cre)25Mgn/0 		involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA MGI:5008146


Genotype
MGI:4848147
cn1
Allelic
Composition		 Ptentm1Hwu/Ptentm1Hwu
Rictortm1.1Mgn/Rictortm1.1Mgn
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Rictortm1.1Mgn mutation (1 available); any Rictor mutation (141 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal prostate gland duct morphology ( J:144810 )
• prostatic ductules of mutants infected with an adenovirus expressing Cre recombinase exhibit a mixed phenotype containing mostly normal, organized epithelial cells and patches of large, disorganized hyperplastic cells; inefficient deletion of Rictor is seen in the patches of disorganized hyperplastic cells
abnormal prostate gland epithelium morphology ( J:144810 )
• prostate tissue histology of mutants infected with an adenovirus expressing Cre recombinase appears normal except that epithelial cells are slightly smaller

reproductive system
abnormal prostate gland duct morphology ( J:144810 )
• prostatic ductules of mutants infected with an adenovirus expressing Cre recombinase exhibit a mixed phenotype containing mostly normal, organized epithelial cells and patches of large, disorganized hyperplastic cells; inefficient deletion of Rictor is seen in the patches of disorganized hyperplastic cells
abnormal prostate gland epithelium morphology ( J:144810 )
• prostate tissue histology of mutants infected with an adenovirus expressing Cre recombinase appears normal except that epithelial cells are slightly smaller

neoplasm
decreased tumor incidence ( J:144810 )
• mutants infected with an adenovirus expressing Cre recombinase do not develop prostate adenocarcinoma




Genotype
MGI:5008147
cn2
Allelic
Composition		 Ptentm1Hwu/Ptentm1Hwu
Rictortm1.1Mgn/Rictortm1.1Mgn
Tg(Ins2-cre)25Mgn/0
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Rictortm1.1Mgn mutation (1 available); any Rictor mutation (141 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreatic beta cell morphology ( J:170129 )
• average beta cell size is increased by 31% compared to controls and by 15% compared to single conditional Pten mutants
• however, mutants show normal beta cell proliferation
decreased pancreatic beta cell mass ( J:170129 )
• beta cell mass is about 40% lower than that of single conditional Pten mutants

growth/size/body
postnatal growth retardation ( J:170129 )

homeostasis/metabolism
abnormal glucose homeostasis ( J:170129 )
• total glucose excursion is lower compared to single conditional Rictor mutants
hypoglycemia ( J:170129 )
• fed blood glucose concentration remains similar to the controls, however mutants show a lower blood glucose concentration at 30 and 60 min after an intraperitoneal glucose bolus compared to single conditional Rictor mutants
decreased circulating insulin level ( J:170129 )
• mutants exhibit lower plasma insulin levels 15 min after glucose challenge and lower total insulin output compared with controls
• however, insulin secretion by glucose stimulated islets is similar to controls and pancreatic insulin content is unchanged




Genotype
MGI:3706134
cn3
Allelic
Composition		 Rictortm1.1Mgn/Rictortm1.2Mgn
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Rictortm1.1Mgn mutation (1 available); any Rictor mutation (141 available)
Rictortm1.2Mgn mutation (0 available); any Rictor mutation (141 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:119564 )
• significantly lower than expected ratio of live embryos were obtained at E13.5 and E17.5, presumed to indicate embryonic lethality




Genotype
MGI:5008146
cn4
Allelic
Composition		 Rictortm1.1Mgn/Rictortm1.1Mgn
Tg(Ins2-cre)25Mgn/0
Genetic
Background		 involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rictortm1.1Mgn mutation (1 available); any Rictor mutation (141 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased pancreatic beta cell mass ( J:170129 )
• beta-cell mass is 28% lower than controls after adjusting for body size
• the reduction in beta cell mass is mainly due to a decrease in beta cell proliferation
• however, beta cell size is unaffected and islet number per pancreatic unit area is unchanged in mutants
abnormal pancreatic beta cell physiology ( J:170129 )
• pancreatic insulin content is about 50% less than controls
decreased pancreatic beta cell proliferation ( J:170129 )
• number of proliferating beta-cells is decreased by 26% compared to controls
decreased insulin secretion ( J:170129 )
• islets have approximately 70% lower insulin secretion in response to glucose than controls
• however, insulin sensitivity is normal

homeostasis/metabolism
abnormal glucose homeostasis ( J:170129 )
• total glucose excursion is higher compared to controls
decreased insulin secretion ( J:170129 )
• islets have approximately 70% lower insulin secretion in response to glucose than controls
• however, insulin sensitivity is normal
hyperglycemia ( J:170129 )
• mutants exhibit hyperglycemia beginning at 12 weeks of age
impaired glucose tolerance ( J:170129 )
• mutants show slower glucose clearance as indicated by elevated blood glucose concentrations at 15 and 30 min after an intraperitoneal glucose bolus
• impaired glucose tolerance is due to reduced pancreatic insulin content and impaired glucose-stimulated insulin secretion

cellular
decreased pancreatic beta cell proliferation ( J:170129 )
• number of proliferating beta-cells is decreased by 26% compared to controls




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12/17/2024
MGI 6.24 		The Jackson Laboratory