Phenotypes associated with this allele

• Allele Symbol: Rictor^tm1.2Mgn
• Allele Name: targeted mutation 1.2, Mark A Magnuson
• Allele ID: MGI:3703322
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rictor^tm1.2Mgn/Rictor^tm1.2Mgn	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL	MGI:3706131
ht2	Rictor^tm1.2Mgn/Rictor^tm1.3Mgn	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL	MGI:3706133
cn3	Rictor^tm1.1Mgn/Rictor^tm1.2Mgn Meox2^tm1(cre)Sor/Meox2^+	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL	MGI:3706134

Genotype
MGI:3706131

hm1

• Allelic Composition: Rictor^tm1.2Mgn/Rictor^tm1.2Mgn
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:119564 )

• expected Mendelian distribution ratios by E9.5 and indistinguishable from either wild-type or heterozygous littermates

• showed growth arrest beginning between E9.5 and E10.5

• live embryos were not observed at E11.5

embryo

decreased embryo size ( J:119564 )

• at E10.5

• histologically normal and no major structural defects in any organ systems were found

abnormal placenta labyrinth morphology ( J:119564 )

• labyrinth layer remains cell dense in most E10.5 mutant placentas

abnormal placental labyrinth vasculature morphology ( J:119564 )

• exhibit fewer maternal-fetal interfaces in most E10.5 mutant placentas

cellular

decreased cell proliferation ( J:119564 )

• growth rate of mouse embryonic fibroblast from E9.5 embryos was slower than that of wild-type counterparts

growth/size/body

decreased embryo size ( J:119564 )

• at E10.5

• histologically normal and no major structural defects in any organ systems were found

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:119564 )

• exhibit fewer maternal-fetal interfaces in most E10.5 mutant placentas

Genotype
MGI:3706133

ht2

• Allelic Composition: Rictor^tm1.2Mgn/Rictor^tm1.3Mgn
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:119564 )

• live embryos were not observed at E11.5

• expected Mendelian distribution ratios by E9.5 and indistinguishable from either wild-type or heterozygous littermates

• showed growth arrest beginning between E9.5 and E10.5

embryo

decreased embryo size ( J:119564 )

• at E10.5

abnormal placenta labyrinth morphology ( J:119564 )

• labyrinth layer remains cell dense in most E10.5 mutant placentas

abnormal placental labyrinth vasculature morphology ( J:119564 )

• exhibit fewer maternal-fetal interfaces in most E10.5 mutant placentas

growth/size/body

decreased embryo size ( J:119564 )

• at E10.5

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:119564 )

• exhibit fewer maternal-fetal interfaces in most E10.5 mutant placentas

Genotype
MGI:3706134

cn3

• Allelic Composition: Rictor^tm1.1Mgn/Rictor^tm1.2Mgn; Meox2^tm1(cre)Sor/Meox2⁺
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:119564 )

• significantly lower than expected ratio of live embryos were obtained at E13.5 and E17.5, presumed to indicate embryonic lethality