Phenotypes associated with this allele

• Allele Symbol: Tg(Tek-Procr)1Cte
• Allele Name: transgene insertion 1, Charles T Esmon
• Allele ID: MGI:3703326
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Procr^tm1Cte/Procr^tm1Cte Tg(Tek-Procr)1Cte/0	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:3703332
tg2	Tg(Tek-Procr)1Cte/0	B6.FVB-Tg(Tek-Procr)1Cte	MGI:3703333

Genotype
MGI:3703332

cx1

• Allelic Composition: Procr^tm1Cte/Procr^tm1Cte; Tg(Tek-Procr)1Cte/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:119529 )

• embryos are detected at E9.5 but none are observed at E12.5

• treatment of pregnant mice with low-molecular weight heparin prolongs embryo survival to E13.5, but no live births

Genotype
MGI:3703333

tg2

• Allelic Composition: Tg(Tek-Procr)1Cte/0
• Genetic Background: B6.FVB-Tg(Tek-Procr)1Cte

hematopoietic system

abnormal platelet physiology ( J:119637 )

• after treatment with high dose of factor Xa/PCPS, platelet consumption is significantly decreased in males compared to wild-type

homeostasis/metabolism

abnormal blood coagulation ( J:119637 )

abnormal platelet physiology ( J:119637 )

• after treatment with high dose of factor Xa/PCPS, platelet consumption is significantly decreased in males compared to wild-type

abnormal enzyme/coenzyme level ( J:119637 )

• after treatment with high dose of factor Xa/PCPS, thrombin generation is decreased in males compared to wild-type

• generation of thrombin antithrombin (TAT) complex is ~4 fold higher in wild-type than in male transgenic mice after treatment

abnormal acute phase protein level ( J:119637 )

• after treatment with high dose of factor Xa/PCPS, fibrinogen consumption is significantly decreased in males compared to wild-type

• fibrinogen levels 18 hours after LPS treatment are slightly higher in transgenic mice than in wild-type littermates

immune system

abnormal immune system physiology ( J:119637 )

• mice show significantly higher levels of circulating antigen presenting cells (APC) in response to LPS

abnormal acute phase protein level ( J:119637 )

• after treatment with high dose of factor Xa/PCPS, fibrinogen consumption is significantly decreased in males compared to wild-type

• fibrinogen levels 18 hours after LPS treatment are slightly higher in transgenic mice than in wild-type littermates

abnormal inflammatory response ( J:119637 )

• transgenic mice are resistant to death induced by LPS doses that are lethal to control wild-type mice; more than 905 of controls die within 60 hour compared to less than 65% of transgenic mice