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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(SV40/HTLV-FCER1A)1Bhk
transgene insertion 1, Beverly H Koller
MGI:3703557
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Fcer1atm1Knt/Fcer1atm1Knt
Tg(SV40/HTLV-FCER1A)1Bhk/0 		either: (involves: 129 * C57BL/6) or (involves: 129 * C57BL/6 * DBA/2) MGI:3703590
cx2
 		Ms4a2tm1Knt/Ms4a2tm1Knt
Tg(SV40/HTLV-FCER1A)1Bhk/0 		involves: 129 * BALB/c MGI:3703595
tg3
 		Tg(SV40/HTLV-FCER1A)1Bhk/0 involves: 129 MGI:3703594


Genotype
MGI:3703590
cx1
Allelic
Composition		 Fcer1atm1Knt/Fcer1atm1Knt
Tg(SV40/HTLV-FCER1A)1Bhk/0
Genetic
Background		 either: (involves: 129 * C57BL/6) or (involves: 129 * C57BL/6 * DBA/2)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1atm1Knt mutation (3 available); any Fcer1a mutation (23 available)
Tg(SV40/HTLV-FCER1A)1Bhk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased vascular permeability ( J:113572 )
• slight change in vascular permeability is observed in anaphylaxis model

immune system
abnormal type I hypersensitivity reaction ( J:113572 )
• mice show a drop in rectal temperature similar to wild-type controls in the model of anaphylaxis; anaphylaxis is restored compared to Fcer1a-null mice




Genotype
MGI:3703595
cx2
Allelic
Composition		 Ms4a2tm1Knt/Ms4a2tm1Knt
Tg(SV40/HTLV-FCER1A)1Bhk/0
Genetic
Background		 involves: 129 * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ms4a2tm1Knt mutation (1 available); any Ms4a2 mutation (12 available)
Tg(SV40/HTLV-FCER1A)1Bhk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:47138 )
• degranulation of bone marrow mast cells (BMMC) induced by antigen-receptor bound IgE crosslinking is 3- to 5-fold reduced compared to those in Ms4a2-heterozygous transgenic mice
decreased susceptibility to type I hypersensitivity reaction ( J:47138 )
• mice show a weaker response (temperature drop) in a model of anaphlaxis (injections of IgE every 12 hours for 36 hours, then antigenic challenge)
abnormal cytokine secretion ( J:47138 )
• Il-6 production in stimulated BMMCs is reduced compared to Ms4a2-heterozygous transgenic mice

hematopoietic system
abnormal mast cell physiology ( J:47138 )
• degranulation of bone marrow mast cells (BMMC) induced by antigen-receptor bound IgE crosslinking is 3- to 5-fold reduced compared to those in Ms4a2-heterozygous transgenic mice




Genotype
MGI:3703594
tg3
Allelic
Composition		 Tg(SV40/HTLV-FCER1A)1Bhk/0
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:47138 )
N
• epidermal Langerhans cells are found at similar levels in mutants and controls; expression levels and patterns of Fcer1a are similar also




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory