Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(APOC3)2674Bres transgene insertion 2674, Jan L Breslow MGI:3703623 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the average fasting plasma triglyceride concentration of homozygous transgenic G2 (G1 x G1) mice was 395 +/- 70 mg/dl, versus 173 +/- 23 for hemizygous transgenic and 58 +/- 8 for nontransgenic littermates
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 7 male G1 transgenic mice deprived of food, but offered 10% sucrose, for 12 hours had triglyceride levels of 141 +/- 24 mg/dl, versus 99 +/- 25 mg/dl in a group of 7 similarly stressed male littermates; eliminating a single outlier in the control group dropped the latter figure to 74 +/- 12 mg/dl, signifcantly different from the Tg value (P < 0.03)
• the area under the 5-hr plasma triglyceride concentration curve of 7 fasting male G1 transgenic mice given a bolus of 400 ul olive oil was significantly greater than that for a similar group of littermate controls (P= 0.01)
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• fasting plasma triglyceride concentrations in 7 male G1 mice averaged 67 +/- 8 mg/dl, versus 49 +/- 6 mg/dl for a similar group of male littermates (P = 0.1)
• fasting plasma triglyceride concentrations in a group of 6 m and 1 f heterozygous G2 mice averaged 173 +/- 23 mg/dl, versus 58 +/- 8 mg/dl for 1m + 2f littermate controls
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• the plasma lipoprotein profile of heterozygous G1 transgenic mice reveals a predominance of particles the size of very low density lipoproteins (VLDL)
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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