Phenotypes associated with this allele

• Allele Symbol: Crym^tm1Sasu
• Allele Name: targeted mutation 1, Satoru Suzuki
• Allele ID: MGI:3703787
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crym^tm1Sasu/Crym^tm1Sasu	129S6.Cg-Crym^tm1Sasu	MGI:3704900

Genotype
MGI:3704900

hm1

• Allelic Composition: Crym^tm1Sasu/Crym^tm1Sasu
• Genetic Background: 129S6.Cg-Crym^tm1Sasu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating thyroxine level ( J:119707 )

• serum concentrations were significantly lower (25%) than in wild-type mice

abnormal triiodothyronine level ( J:119707 )

• peak absorption of radioactive T3 occurs 1 hour post-injection then sharply decreases in homozygotes compared to a peak in absorption at 4 hours then slow decrease in wild-type mice

• however, there is no difference in serum radioactivity at 8 hours after injection

decreased circulating triiodothyronine level ( J:119707 )

• serum concentrations were significantly lower (13%) than in wild-type mice

growth/size/body

growth/size/body region phenotype ( J:119707 )

N • despite decreases in circulating thyroid hormone levels, growth rate is not different from wild-type

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:119707 )

N • despite decreases in circulating thyroid hormone levels no histological defects are detected in the pituitary or thyroid gland

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:119707 )

N • despite association of point mutations in this gene to deafness in humans, no hearing deficits are detected

cardiovascular system

cardiovascular system phenotype ( J:119707 )

N • on a low iodide diet no difference in heart rate is detected