All Phenotypes Prdm1<tm2Masu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺ Prdm1^tm2Masu/Prdm1^tm2Masu	involves: 129P2/OlaHsd * 129X1/SvJ	MGI:5762939
cn2	Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺ Prdm1^tm2Masu/Prdm1^tm2Masu	involves: 129P2/OlaHsd * C57BL/6	MGI:5762938

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

enlarged spleen ( J:167612 )

• splenomegaly in all terminally ill mice

abnormal plasma cell differentiation ( J:167612 )

• plasma cell formation is severely impeded 10 days after primary and secondary immunization

increased germinal center B cell number ( J:167612 )

• mice show increased numbers of germinal center B cells at day 10 after primary immunizations

abnormal germinal center B cell physiology ( J:167612 )

• small, but significant, increase of the fraction of germinal center B cells in the S and G2 phases of the cell cycle

decreased IgG1 level ( J:167612 )

• reduction in total as well as sheep red blood cell-specific IgG1, but not IgM, antibodies 10 days after primary and secondary immunization

immune system

enlarged spleen ( J:167612 )

• splenomegaly in all terminally ill mice

abnormal plasma cell differentiation ( J:167612 )

• plasma cell formation is severely impeded 10 days after primary and secondary immunization

increased germinal center B cell number ( J:167612 )

• mice show increased numbers of germinal center B cells at day 10 after primary immunizations

abnormal germinal center B cell physiology ( J:167612 )

• small, but significant, increase of the fraction of germinal center B cells in the S and G2 phases of the cell cycle

decreased IgG1 level ( J:167612 )

• reduction in total as well as sheep red blood cell-specific IgG1, but not IgM, antibodies 10 days after primary and secondary immunization

enlarged lymph nodes ( J:167612 )

• occasional lymphadenopathy

liver/biliary system

enlarged liver ( J:167612 )

• hepatomegaly in one mouse

mortality/aging

decreased survivor rate ( J:167612 )

• shortened survival

premature death ( J:167612 )

• shortened survival

neoplasm

increased B cell derived lymphoma incidence ( J:167612 )

• spleens and lymph nodes show presence of large cells with a diffuse growth pattern, resembling diffuse large B cell lymphoma (DLBCL)

• lymphoproliferations are of clonal origin

• 5 of 6 DLBCLs are consistent with activated B cell-DLBCL

growth/size/body

enlarged liver ( J:167612 )

• hepatomegaly in one mouse

enlarged spleen ( J:167612 )

• splenomegaly in all terminally ill mice

Allelic Composition	Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺ Prdm1^tm2Masu/Prdm1^tm2Masu
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky} mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Prdm1^tm2Masu mutation (1 available); any Prdm1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal plasma cell differentiation ( J:167612 )

• plasma cell formation is severely impeded 10 days after primary and secondary immunization

increased germinal center B cell number ( J:167612 )

• mice show increased numbers of germinal center B cells at day 10 after primary immunizations

abnormal germinal center B cell physiology ( J:167612 )

• small, but significant, increase of the fraction of germinal center B cells in the S and G2 phases of the cell cycle

decreased IgG1 level ( J:167612 )

• reduction in total as well as sheep red blood cell-specific IgG1, but not IgM, antibodies 10 days after primary and secondary immunization

immune system

abnormal plasma cell differentiation ( J:167612 )

• plasma cell formation is severely impeded 10 days after primary and secondary immunization

increased germinal center B cell number ( J:167612 )

• mice show increased numbers of germinal center B cells at day 10 after primary immunizations

abnormal germinal center B cell physiology ( J:167612 )

• small, but significant, increase of the fraction of germinal center B cells in the S and G2 phases of the cell cycle

decreased IgG1 level ( J:167612 )

• reduction in total as well as sheep red blood cell-specific IgG1, but not IgM, antibodies 10 days after primary and secondary immunization

mortality/aging

decreased survivor rate ( J:167612 )

premature death ( J:167612 )

• shortened survival, with 40% survival at around 500 days of age

neoplasm

increased B cell derived lymphoma incidence ( J:167612 )

• mice succumb to a B cell-derived lymphoproliferative disease affecting spleen and lymph nodes, resembling human diffuse large B cell lymphoma

• mice develop clonal lymphomas consistent with activated B cell-diffuse large B cell lymphoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
non-Hodgkin lymphoma		DOID:0060060	OMIM:605027	J:167612

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