Phenotypes associated with this allele

• Allele Symbol: Tg(Lbx1-cre)3Cbm
• Allele Name: transgene insertion 3, Carmen Birchmeier
• Allele ID: MGI:3704929
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rbpj^tm1Hon/Rbpj^tm1Hon Tg(Lbx1-cre)3Cbm/0	involves: 129P2/OlaHsd	MGI:3706967

Genotype
MGI:3706967

cn1

• Allelic Composition: Rbpj^tm1Hon/Rbpj^tm1Hon; Tg(Lbx1-cre)3Cbm/0
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:120053 )

• expected Mendelian ratios of mice are born but homozygotes fail to suckle and subsequently die within the first postnatal day

muscle

abnormal myogenesis ( J:120053 )

• at E11.5, more progenitor cells have started to differentiate (indicated by increased Myod expression)

• at E12.5 in the limbs, more cells express markers of myogenic differentiation and fewer progenitor cells remain

• at E14.5 in the limbs, fewer muscle progenitor cells are present and those present have reduced proliferative capacity

• at E18.5 all cells are postmitotic unlike in wild-type

• however, the muscle progenitor cells migration is unaffected

hypaxial muscle hypoplasia ( J:120053 )

• at E14.5 there is a reduction in the size of limb muscle groups

decreased satellite cell number ( J:120053 )

• absence of satellite cells in limb muscle at E18.5

• very few satellite cells are seen in intrinsic tongue muscle at E14.5 however, satellite cells can be detected in the distal forelimb

decreased skeletal muscle fiber density ( J:120053 )

• muscle fibers in limb muscle have reduced density and the ratio of Myod+ nuclei/fiber is reduced

• however, myofiber diameter is comparable to wild-type

behavior/neurological

abnormal suckling behavior ( J:120053 )

• homozygotes fail to suckle