All Phenotypes H1f7<tm1Yoni> MGI Mouse

abnormal spermatogenesis ( J:119846 )

• sperm nuclear membranes are undulated and the nuclei invaginated clear halos are seen inside the nuclear membrane of mature spermatids and epididymal sperm

• clear halos are seen inside the nuclear membrane of mature spermatids and epididymal sperm

teratozoospermia ( J:119846 )

• sperm have abnormal kinks in the tail and abnormally shaped heads

• however, the number of sperm in homozygote mice recovered from the cauda epididymides were similar to heterozygote mice

• sperm have dislocated necks and heads of mature spermatids (after step 5) and sperm are abnormal with remnants of cytoplasm around the nucleus, deformations, or vacuolation of the acrosomes are present

male infertility ( J:119846 )

• only males are infertile

• however, testes and seminal vesicles appear normal

impaired fertilization ( J:119846 )

• sperm fail to fertilize eggs by in vitro fertilization

• however, sperm can bind to the zona pellucida in vitro and sperm can support fertilization and embryo development after intra cytoplasmic sperm injection

abnormal sperm physiology ( J:119846 )

• treatment of sperm with beta-mercaptoethanol results in loss of sperm integrity unlike heterozygous and wild-type sperm

• increased access of nuclear DNA of sperm to propidium iodide determined by a higher fluorescence peak

asthenozoospermia ( J:119846 )

• decrease in the ratio of motile sperm, measurable sperm velocities, and amplitude of the lateral head displacement after 1 to 6 hours incubation compared to control mice