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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Brca1tm1Aash
targeted mutation 1, Alan Ashworth
MGI:3706167
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Brca1tm1Aash/Brca1tm1Aash involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3710353
cn2
Brca1tm1Aash/Brca1tm1Aash
Trp53tm1Brd/Trp53+
Tg(LGB-cre)74Acl/0
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * CBA MGI:3710354
cn3
Brca1tm1Aash/Brca1tm1Aash
Tg(LGB-cre)74Acl/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3710355


Genotype
MGI:3710353
hm1
Allelic
Composition
Brca1tm1Aash/Brca1tm1Aash
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Aash mutation (3 available); any Brca1 mutation (114 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice have no overt phenotype and normal lifespans




Genotype
MGI:3710354
cn2
Allelic
Composition
Brca1tm1Aash/Brca1tm1Aash
Trp53tm1Brd/Trp53+
Tg(LGB-cre)74Acl/0
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Aash mutation (3 available); any Brca1 mutation (114 available)
Tg(LGB-cre)74Acl mutation (2 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• some (2/59) develop salivary gland malignant myoepithelial tumors
• mice develop mammary gland tumors with higher frequency (64%; 25/39 animals) and shorter latency of 6-46 weeks (all but one tumor had developed by 31 weeks) relative to control mice; 6/39 mice had multiple tumors in the same and in adjacent glands
• tumors develop in the inguinal and thoracic glands with equal frequency, and on both sides of the body
• majority of tumors (30/33) show marked nuclear pleomorphism; central necrosis is seen in about 67% of tumors (23/32)
• most (29/33) neoplasms show mixed pushing and infiltrative borders, while only 4/33 showed a prominent inflammatory infiltrate
• most (29/33) tumors show homologous metaplastic elements in form of squamous or spindly differentiation
• high grade ductal carcinoma in situ (DCIS) is observed admixed with, or adjacent to, the invasive tumor in some cases, and occasionally columnar cell lesions with cytological atypia are seen with those tumors; columnar cell changes are found in adjacent tissue in a few tumors

endocrine/exocrine glands
• some (2/59) develop salivary gland malignant myoepithelial tumors
• only 2/33 tumors show beta-catenin upregulation that was restricted to areas of squamous differentiation and basaloid cells
• mice develop mammary gland tumors with higher frequency (64%; 25/39 animals) and shorter latency of 6-46 weeks (all but one tumor had developed by 31 weeks) relative to control mice; 6/39 mice had multiple tumors in the same and in adjacent glands
• tumors develop in the inguinal and thoracic glands with equal frequency, and on both sides of the body
• majority of tumors (30/33) show marked nuclear pleomorphism; central necrosis is seen in about 67% of tumors (23/32)
• most (29/33) neoplasms show mixed pushing and infiltrative borders, while only 4/33 showed a prominent inflammatory infiltrate
• most (29/33) tumors show homologous metaplastic elements in form of squamous or spindly differentiation
• high grade ductal carcinoma in situ (DCIS) is observed admixed with, or adjacent to, the invasive tumor in some cases, and occasionally columnar cell lesions with cytological atypia are seen with those tumors; columnar cell changes are found in adjacent tissue in a few tumors

integument
• only 2/33 tumors show beta-catenin upregulation that was restricted to areas of squamous differentiation and basaloid cells
• mice develop mammary gland tumors with higher frequency (64%; 25/39 animals) and shorter latency of 6-46 weeks (all but one tumor had developed by 31 weeks) relative to control mice; 6/39 mice had multiple tumors in the same and in adjacent glands
• tumors develop in the inguinal and thoracic glands with equal frequency, and on both sides of the body
• majority of tumors (30/33) show marked nuclear pleomorphism; central necrosis is seen in about 67% of tumors (23/32)
• most (29/33) neoplasms show mixed pushing and infiltrative borders, while only 4/33 showed a prominent inflammatory infiltrate
• most (29/33) tumors show homologous metaplastic elements in form of squamous or spindly differentiation
• high grade ductal carcinoma in situ (DCIS) is observed admixed with, or adjacent to, the invasive tumor in some cases, and occasionally columnar cell lesions with cytological atypia are seen with those tumors; columnar cell changes are found in adjacent tissue in a few tumors

digestive/alimentary system
• some (2/59) develop salivary gland malignant myoepithelial tumors

growth/size/body
• some (2/59) develop salivary gland malignant myoepithelial tumors

craniofacial
• some (2/59) develop salivary gland malignant myoepithelial tumors




Genotype
MGI:3710355
cn3
Allelic
Composition
Brca1tm1Aash/Brca1tm1Aash
Tg(LGB-cre)74Acl/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Aash mutation (3 available); any Brca1 mutation (114 available)
Tg(LGB-cre)74Acl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• some mice (which have not gone through pregnancies) develop salivary gland myoepithelial tumors
• mammary tumors occur in these control mice at lower frequency (12%: 5/43 animals) and much longer latency (12-15 months) compared to mice on a Trp43-haploinsufficient background

integument
• mammary tumors occur in these control mice at lower frequency (12%: 5/43 animals) and much longer latency (12-15 months) compared to mice on a Trp43-haploinsufficient background

endocrine/exocrine glands
• some mice (which have not gone through pregnancies) develop salivary gland myoepithelial tumors
• mammary tumors occur in these control mice at lower frequency (12%: 5/43 animals) and much longer latency (12-15 months) compared to mice on a Trp43-haploinsufficient background

digestive/alimentary system
• some mice (which have not gone through pregnancies) develop salivary gland myoepithelial tumors

growth/size/body
• some mice (which have not gone through pregnancies) develop salivary gland myoepithelial tumors

craniofacial
• some mice (which have not gone through pregnancies) develop salivary gland myoepithelial tumors

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:119996





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory