Phenotypes associated with this allele

• Allele Symbol: Lzts1^tm1Cro
• Allele Name: targeted mutation 1, Carlo M Croce
• Allele ID: MGI:3706174
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lzts1^tm1Cro/Lzts1^tm1Cro	involves: 129 * C57BL/6J	MGI:3710365
ht2	Lzts1^tm1Cro/Lzts1^+	involves: 129 * C57BL/6J	MGI:3710364

Genotype
MGI:3710365

hm1

• Allelic Composition: Lzts1^tm1Cro/Lzts1^tm1Cro
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

increased stomach tumor incidence ( J:119989 )

• 100% of mice (20/20) treated with N-nitrosomethylbenzylamine (NMBA) develop multiple tumors of the forestomach by 6 weeks posttreatment compared to 17% (5/30 mice) of wild-type

increased gastric adenocarcinoma incidence ( J:119989 )

• mice develop invasive carcinoma of the forestomach at high frequency compared with wild-type which mostly show thin and regular epithelia

neoplasm

increased tumor incidence ( J:119989 )

• 9/9 mice develop multiple tumors; age of onset is about 17 months

increased stomach tumor incidence ( J:119989 )

• 100% of mice (20/20) treated with N-nitrosomethylbenzylamine (NMBA) develop multiple tumors of the forestomach by 6 weeks posttreatment compared to 17% (5/30 mice) of wild-type

increased gastric adenocarcinoma incidence ( J:119989 )

• mice develop invasive carcinoma of the forestomach at high frequency compared with wild-type which mostly show thin and regular epithelia

increased mammary gland tumor incidence ( J:119989 )

• mice develop mammary tumors

increased lymphoma incidence ( J:119989 )

• observed with higher penetrance (100%) than in heterozygotes (35%)

increased carcinoma incidence ( J:119989 )

increased hepatocellular carcinoma incidence ( J:119989 )

• observed with higher penetrance (75%) than in heterozygotes (50%)

increased lung adenocarcinoma incidence ( J:119989 )

increased sarcoma incidence ( J:119989 )

• soft tissue sarcomas occur

• observed with higher penetrance (100%) than in heterozygotes (0%)

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:119989 )

• mice develop mammary tumors

cellular

abnormal cell cycle ( J:119989 )

• mutant MEFs have an increased exit from mitosis after treatment with nocodazole compared to wild-type cells

abnormal fibroblast physiology ( J:119989 )

• mouse embryonic fibroblasts (MEFs) transfected with an adenovirus show much higher susceptibility to transformation compared to wild-type MEFs

increased fibroblast apoptosis ( J:119989 )

• cultured MEFs show increased levels of apoptosis during logarithmic phase of growth

decreased fibroblast proliferation ( J:119989 )

• mouse embryonic fibroblasts (MEFs) grow more slowly in culture over a 6 day period compared to wild-type

integument

increased mammary gland tumor incidence ( J:119989 )

• mice develop mammary tumors

liver/biliary system

increased hepatocellular carcinoma incidence ( J:119989 )

• observed with higher penetrance (75%) than in heterozygotes (50%)

respiratory system

increased lung adenocarcinoma incidence ( J:119989 )

Genotype
MGI:3710364

ht2

• Allelic Composition: Lzts1^tm1Cro/Lzts1⁺
• Genetic Background: involves: 129 * C57BL/6J

neoplasm

increased tumor incidence ( J:119989 )

• 12/20 mice develop multiple tumors; age of onset is about 19 months

increased stomach tumor incidence ( J:119989 )

• 100% of mice (33/33) treated with N-nitrosomethylbenzylamine (NMBA) develop multiple tumors of the forestomach by 6 weeks posttreatment compared to 17% (5/30 mice) of wild-type

increased gastric adenocarcinoma incidence ( J:119989 )

• mice develop invasive carcinoma of the forestomach at high frequency compared with wild-type which mostly show thin and regular epithelia

increased mammary gland tumor incidence ( J:119989 )

• mice develop mammary tumors

increased lung adenoma incidence ( J:119989 )

• some tumors are lung adenomas

increased lymphoma incidence ( J:119989 )

increased carcinoma incidence ( J:119989 )

increased hepatocellular carcinoma incidence ( J:119989 )

liver/biliary system

increased hepatocellular carcinoma incidence ( J:119989 )

digestive/alimentary system

increased stomach tumor incidence ( J:119989 )

• 100% of mice (33/33) treated with N-nitrosomethylbenzylamine (NMBA) develop multiple tumors of the forestomach by 6 weeks posttreatment compared to 17% (5/30 mice) of wild-type

increased gastric adenocarcinoma incidence ( J:119989 )

• mice develop invasive carcinoma of the forestomach at high frequency compared with wild-type which mostly show thin and regular epithelia

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:119989 )

• mice develop mammary tumors

integument

increased mammary gland tumor incidence ( J:119989 )

• mice develop mammary tumors

respiratory system

increased lung adenoma incidence ( J:119989 )

• some tumors are lung adenomas