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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Srpxtm1Hzi
targeted mutation 1, Hirokazu Inoue
MGI:3706175
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Srpxtm1Hzi/Srpxtm1Hzi involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3707365
ht2
 		Srpxtm1Hzi/Srpx+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3707366


Genotype
MGI:3707365
hm1
Allelic
Composition		 Srpxtm1Hzi/Srpxtm1Hzi
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srpxtm1Hzi mutation (1 available); any Srpx mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:119999 )
• between 7 and 12 months of age, ~30% (14/46) of mice developed malignant tumors compared to no tumors in wild-type controls up to 12 months after birth
increased hepatoma incidence ( J:119999 )
• 3/14 tumors were hepatomas
increased lymphoma incidence ( J:119999 )
• 6/14 tumors were lymphomas; tumors of the mesenteric lymph nodes were found in the intestine
increased T cell derived lymphoma incidence ( J:119999 )
• lymphomas were determined to be derived from T cells
increased lung adenocarcinoma incidence ( J:119999 )
• 4/14 tumors were adenocarcinomas
increased sarcoma incidence ( J:119999 )
• 1/14 tumors was a sarcoma

hematopoietic system
increased T cell derived lymphoma incidence ( J:119999 )
• lymphomas were determined to be derived from T cells
enlarged spleen ( J:119999 )
• spleens of mutants with lymphomas were enlarged compared to wild-type spleens
abnormal lymphocyte morphology ( J:119999 )
• atypical lymphocytes were detected growing in mesenteric lymph node, kidneys, liver, and spleen

immune system
increased T cell derived lymphoma incidence ( J:119999 )
• lymphomas were determined to be derived from T cells
enlarged spleen ( J:119999 )
• spleens of mutants with lymphomas were enlarged compared to wild-type spleens
abnormal lymphocyte morphology ( J:119999 )
• atypical lymphocytes were detected growing in mesenteric lymph node, kidneys, liver, and spleen

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:119999 )
• lymphomas were determined to be derived from T cells

growth/size/body
enlarged spleen ( J:119999 )
• spleens of mutants with lymphomas were enlarged compared to wild-type spleens

liver/biliary system
increased hepatoma incidence ( J:119999 )
• 3/14 tumors were hepatomas

respiratory system
increased lung adenocarcinoma incidence ( J:119999 )
• 4/14 tumors were adenocarcinomas




Genotype
MGI:3707366
ht2
Allelic
Composition		 Srpxtm1Hzi/Srpx+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srpxtm1Hzi mutation (1 available); any Srpx mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lymphoma incidence ( J:119999 )
• between 7 and 12 months, 2/20 mice develop lymohomas, compared to no tumors in wild-type controls up to 12 months after birth




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory