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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Artm1Fcl
targeted mutation 1, Frank Claessens
MGI:3706240
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Artm1Fcl/Artm1Fcl involves: 129S2/SvPas * C57BL/6 MGI:3707324
ot2
 		Artm1Fcl/Y involves: 129S2/SvPas * C57BL/6 MGI:3707323


Genotype
MGI:3707324
hm1
Allelic
Composition		 Artm1Fcl/Artm1Fcl
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm1Fcl mutation (1 available); any Ar mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:120102 )
• female homozygotes are viable and fertile




Genotype
MGI:3707323
ot2
Allelic
Composition		 Artm1Fcl/Y
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm1Fcl mutation (1 available); any Ar mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Histochemical analysis of wild type and Artm1Fcl/Y testes

cellular
decreased germ cell number ( J:120102 )
• total number of germ cells is reduced to 55% that of controls

reproductive system
decreased germ cell number ( J:120102 )
• total number of germ cells is reduced to 55% that of controls
decreased prostate gland anterior lobe weight ( J:120102 )
• anterior prostate weight is 67% of wild-type weight at 11 weeks of age
decreased prostate gland ventral lobe weight ( J:120102 )
• ventral prostate weight is reduced to 54% of wild-type weight at 11 weeks of age
decreased seminal vesicle weight ( J:120102 )
• seminal vesicles are reduced to 55% of wild-type weight at 11 weeks of age
decreased Sertoli cell number ( J:120102 )
• total number of Sertoli cells is reduced to 68% of controls (expressed as nuclear volume/testis)
small seminiferous tubules ( J:120102 )
• seminiferous tubules have reduced diameters (~85% of wild-type)
decreased testis weight ( J:120102 )
• testis weight is reduced to 67% of wild-type at 11 weeks of age
decreased epididymis weight ( J:120102 )
• weight is reduced to 56% of wild-type weight at 11 weeks of age
decreased litter size ( J:120102 )
• litters sired by mutant males are reduced 2-fold in size and 4-fold in frequency
reduced male fertility ( J:120102 )
• males display reduced fertility based upon decreased litter size and frequency

endocrine/exocrine glands
decreased prostate gland anterior lobe weight ( J:120102 )
• anterior prostate weight is 67% of wild-type weight at 11 weeks of age
decreased prostate gland ventral lobe weight ( J:120102 )
• ventral prostate weight is reduced to 54% of wild-type weight at 11 weeks of age
decreased seminal vesicle weight ( J:120102 )
• seminal vesicles are reduced to 55% of wild-type weight at 11 weeks of age
decreased Sertoli cell number ( J:120102 )
• total number of Sertoli cells is reduced to 68% of controls (expressed as nuclear volume/testis)
small seminiferous tubules ( J:120102 )
• seminiferous tubules have reduced diameters (~85% of wild-type)
decreased testis weight ( J:120102 )
• testis weight is reduced to 67% of wild-type at 11 weeks of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory