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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gins1tm1Ntak
targeted mutation 1, Nobuyuki Takakura
MGI:3706309
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gins1tm1Ntak/Gins1tm1Ntak involves: 129P2/OlaHsd * C57BL/6J MGI:3707354


Genotype
MGI:3707354
hm1
Allelic
Composition
Gins1tm1Ntak/Gins1tm1Ntak
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gins1tm1Ntak mutation (0 available); any Gins1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• apoptotic cells appear in ICM of mutant blastocyst cultures on day 5, while heterozygous blastocysts continuously proliferate after 10 days of culture
• in culture, trophoblasts attach to the dish, but ICM cells fail to form outgrowths
• ICM cells stop proliferating, while trophoblast cells continue to proliferate
• embryos fail to develop past E5.5; at E6.5, wild-type embryos have a cylinder-like 2-layered structure, but homozygotes lack this structure
• at E6.5, homozygotes display disorganized embryonic structures
• at E6.5, homozygotes display disorganized extraembryonic structures

cellular
• apoptotic cells appear in ICM of mutant blastocyst cultures on day 5, while heterozygous blastocysts continuously proliferate after 10 days of culture
• in culture, trophoblasts attach to the dish, but ICM cells fail to form outgrowths
• ICM cells stop proliferating, while trophoblast cells continue to proliferate





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory