Phenotypes associated with this allele

• Allele Symbol: Ppargc1b^tm1.1Rev
• Allele Name: targeted mutation 1.1, Ronald M Evans
• Allele ID: MGI:3706314
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppargc1b^tm1.1Rev/Ppargc1b^tm1.1Rev	involves: 129 * C57BL/6J	MGI:3707218

Genotype
MGI:3707218

hm1

• Allelic Composition: Ppargc1b^tm1.1Rev/Ppargc1b^tm1.1Rev
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased liver weight ( J:120079 )

• after 12 weeks on a high fat diet, mutants show increased liver to body weight ratio

mortality/aging

postnatal lethality, incomplete penetrance ( J:120079 )

• homozygous mice found at weaning are less than expected (17% instead of 25%)

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:120079 )

N • oxygen consumption, carbon dioxide production, respiratory exchange ratio, food consumption, and body weight up to at least 6 months of age are similar to controls

impaired adaptive thermogenesis ( J:120079 )

• when exposed to temperature of 4 degrees from thermoneutrality, mutants show dramatic hypothermia and morbidity whereas wild-type do not; after 5 hours of cold exposure, core body temperature of mutants is between 20 and 31.7 degrees compared to core temperatures between 34.4 and 36.5 degrees for wild-type

decreased circulating free fatty acids level ( J:120079 )

• serum FFA levels are reduced relative to controls

increased circulating free fatty acids level ( J:120079 )

• after 7 weeks on a high fat diet, serum FFA levels are increased relative to controls

decreased circulating triglyceride level ( J:120079 )

• serum levels are reduced compared to controls

increased circulating triglyceride level ( J:120079 )

• after 7 weeks on a high fat diet, serum levels are increased compared to controls

increased liver triglyceride level ( J:120079 )

• after 12 weeks on a high fat diet, mutants show increased triglyceride levels in the liver

liver/biliary system

increased liver weight ( J:120079 )

• after 12 weeks on a high fat diet, mutants show increased liver to body weight ratio

increased liver triglyceride level ( J:120079 )

• after 12 weeks on a high fat diet, mutants show increased triglyceride levels in the liver

macrovesicular hepatic steatosis ( J:120079 )

• when fed a high fat diet for 7-8 weeks, mutants show similar weight gain, insulin and glucose parameters relative to wild-type; after 12 weeks on a high fat diet, mutants show increased liver to body weight ratio, increased triglyceride levels in the liver, and presence of large lipid droplets in the liver

behavior/neurological

decreased locomotor activity ( J:120079 )

• mutants have greatly decreased motor activity during the dark cycle