immune system
N |
• regulatory T cells exhibit normal cell proliferation and survival
|
• dendritic cell-intrinsic reduction in regulatory T cell development from bone marrow cells transplanted into irradiated host mice
• however, deletion of blood-borne, antigen-specific CD4 single positive thymocytes is normal
|
• splenic dendritic cells show increased MHC class II surface expression relative to wild-type
|
• internalization of MHC class II surface molecules appears to be greater in mutants relative to wild-type
• internalized MHC class II molecules are localized to the recycling compartment, while in wild-type, these molecules localize to the lysosomal compartment
|
• dendritic cells are unable to present a GFP-fused I-Ealpha antigen unlike similarly treated wild-type mice
(J:157516)
• increased
(J:201198)
|
• MHC class II molecule surface expression is upregulated in blood-circulating B cells
|
• in CD8+ and CD8- dendritic cells following LPS or anti-CD40 antibody stimulation
|
• in CD8+ and CD8- dendritic cells following LPS or anti-CD40 antibody stimulation
|
hematopoietic system
• dendritic cell-intrinsic reduction in regulatory T cell development from bone marrow cells transplanted into irradiated host mice
• however, deletion of blood-borne, antigen-specific CD4 single positive thymocytes is normal
|
• splenic dendritic cells show increased MHC class II surface expression relative to wild-type
|
• internalization of MHC class II surface molecules appears to be greater in mutants relative to wild-type
• internalized MHC class II molecules are localized to the recycling compartment, while in wild-type, these molecules localize to the lysosomal compartment
|