Phenotypes associated with this allele

• Allele Symbol: P4ha1^tm1Jomy
• Allele Name: targeted mutation 1, Johanna Myllyharju
• Allele ID: MGI:3706369
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	P4ha1^tm1Jomy/P4ha1^tm1Jomy	involves: 129/Sv * C57BL	MGI:3707714

Genotype
MGI:3707714

hm1

• Allelic Composition: P4ha1^tm1Jomy/P4ha1^tm1Jomy
• Genetic Background: involves: 129/Sv * C57BL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:120302 )

• mice die between E10.5 and E11.5

embryo

embryonic growth retardation ( J:120302 )

• development is delayed after E9.0

decreased embryo size ( J:120302 )

• at E10.5 embryos are small and fragile compared to wild-type

abnormal limb mesenchyme morphology ( J:120302 )

• at E10.5 in the developing limb bud, mesenchymal cell density is reduced, cell-cell contacts are rare, and cells have fewer filopodia

growth/size/body

embryonic growth retardation ( J:120302 )

• development is delayed after E9.0

decreased embryo size ( J:120302 )

• at E10.5 embryos are small and fragile compared to wild-type

cardiovascular system

abnormal capillary morphology ( J:120302 )

• at E10.5 capillary walls are frequently ruptured and usually empty of red blood cells

• however, capillary density is similar to wild-type

cellular

abnormal endoplasmic reticulum morphology ( J:120302 )

• at E10.5, the endoplasmic reticulum is dilated

impaired basement membrane formation ( J:120302 )

• mice lack a distinct basal membrane structure and assembly of insoluble supramolecular collagen structures is impaired

integument

pallor ( J:120302 )

limbs/digits/tail

abnormal limb mesenchyme morphology ( J:120302 )

• at E10.5 in the developing limb bud, mesenchymal cell density is reduced, cell-cell contacts are rare, and cells have fewer filopodia