Phenotypes associated with this allele

• Allele Symbol: Nxph3^tm1.1Mami
• Allele Name: targeted mutation 1.1, Markus Missler
• Allele ID: MGI:3706428
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nxph3^tm1.1Mami/Nxph3^tm1.1Mami	involves: 129P2/OlaHsd * C57BL/6J * FVB/N	MGI:3706515
cx2	Nxph1^tm1Sud/Nxph1^tm1Sud Nxph3^tm1.1Mami/Nxph3^tm1.1Mami	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/N	MGI:3706517

Genotype
MGI:3706515

hm1

• Allelic Composition: Nxph3^tm1.1Mami/Nxph3^tm1.1Mami
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:119861 )

N • mice are fertile

behavior/neurological

abnormal spatial learning ( J:119861 )

• significant increase in swimming speed in Morris water maze resulting in shorter escape latencies

increased startle reflex ( J:119861 )

• two-fold increase in acoustic startle response compared to wild-type

impaired coordination ( J:119861 )

• shorter latencies to fall off a rotating drum at speed from 16 to 32 rpm

abnormal locomotor behavior ( J:119861 )

• significant increase in swimming speed

• however, natural roaming and exploration behavior are not altered

nervous system

nervous system phenotype ( J:119861 )

N • no differences in brain layering, cell density, cortical lamination or lobules 9 or 10 in the cerebellum

N • no difference in marker proteins for excitatory or inhibitory synapses

Genotype
MGI:3706517

cx2

• Allelic Composition: Nxph1^tm1Sud/Nxph1^tm1Sud; Nxph3^tm1.1Mami/Nxph3^tm1.1Mami
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/N

mortality/aging

mortality/aging ( J:119861 )

N • no change in viability compared to wild-type mice

growth/size/body

growth/size/body region phenotype ( J:119861 )

N • body weight is not different from wild-type