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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tyk2E775K
E775K
MGI:3706656
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tyk2E775K/Tyk2E775K B10.D1-H2q/SgJ MGI:3706897


Genotype
MGI:3706897
hm1
Allelic
Composition		 Tyk2E775K/Tyk2E775K
Genetic
Background		 B10.D1-H2q/SgJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyk2E775K mutation (1 available); any Tyk2 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgG level ( J:69051 )
• mice exhibit defective IgG2a and IgG1 production in response to collagen
abnormal T-helper 1 physiology ( J:69051 )
• mice exhibit deficient Th1 response following collagen immunization
increased circulating interleukin-12 level ( J:120304 )
• mice exhibit elevated levels of circulating IL12 over control (B10.Q/Ai) in response to infection
decreased interferon-gamma secretion ( J:69051 , J:120304 )
• cells obtained from lymph nodes of collagen immunized mice fail to produce interferon gamma in response to nominal antigen (J:69051)
• mice exhibit reduced levels of interferon gamma in response to protozoan infection prior to day 8, however, interferon gamma levels exceed control (B10.Q/Ai) after day 8 (J:120304)
increased susceptibility to parasitic infection ( J:120304 )
• inoculated mice succumb to Toxoplasma gondii infection with 10-14 days

skeleton

homeostasis/metabolism
increased circulating interleukin-12 level ( J:120304 )
• mice exhibit elevated levels of circulating IL12 over control (B10.Q/Ai) in response to infection

hematopoietic system
decreased IgG level ( J:69051 )
• mice exhibit defective IgG2a and IgG1 production in response to collagen
abnormal T-helper 1 physiology ( J:69051 )
• mice exhibit deficient Th1 response following collagen immunization




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory