All Phenotypes Tyk2<E775K> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tyk2^E775K
E775K
MGI:3706656

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tyk2^E775K/Tyk2^E775K	B10.D1-H2^q/SgJ	MGI:3706897

Allelic Composition	Tyk2^E775K/Tyk2^E775K
Genetic Background	B10.D1-H2^q/SgJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyk2^E775K mutation (1 available); any Tyk2 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased IgG level ( J:69051 )

• mice exhibit defective IgG2a and IgG1 production in response to collagen

decreased IgG1 level ( J:69051 )

decreased IgG2a level ( J:69051 )

abnormal T-helper 1 physiology ( J:69051 )

• mice exhibit deficient Th1 response following collagen immunization

increased circulating interleukin-12 level ( J:120304 )

• mice exhibit elevated levels of circulating IL12 over control (B10.Q/Ai) in response to infection

decreased interferon-gamma secretion ( J:69051 , J:120304 )

• cells obtained from lymph nodes of collagen immunized mice fail to produce interferon gamma in response to nominal antigen (J:69051)

• mice exhibit reduced levels of interferon gamma in response to protozoan infection prior to day 8, however, interferon gamma levels exceed control (B10.Q/Ai) after day 8 (J:120304)

decreased susceptibility to induced arthritis ( J:69051 )

increased susceptibility to parasitic infection ( J:120304 )

• inoculated mice succumb to Toxoplasma gondii infection with 10-14 days

skeleton

decreased susceptibility to induced arthritis ( J:69051 )

homeostasis/metabolism

increased circulating interleukin-12 level ( J:120304 )

• mice exhibit elevated levels of circulating IL12 over control (B10.Q/Ai) in response to infection

hematopoietic system

decreased IgG level ( J:69051 )

• mice exhibit defective IgG2a and IgG1 production in response to collagen

decreased IgG1 level ( J:69051 )

decreased IgG2a level ( J:69051 )

abnormal T-helper 1 physiology ( J:69051 )

• mice exhibit deficient Th1 response following collagen immunization

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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