Phenotypes associated with this allele

• Allele Symbol: Dbnl^{Gt(betageo)11Byg}
• Allele Name: gene trap 11, BayGenomics
• Allele ID: MGI:3706950
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dbnl^Gt(betageo)11Byg/Dbnl^Gt(betageo)11Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3710140

Genotype
MGI:3710140

hm1

• Allelic Composition: Dbnl^{Gt(betageo)11Byg}/Dbnl^{Gt(betageo)11Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:119847 )

• non-Mendelian ratios are born (28% wild-type, 55.5% heterozygotes and 16.6% homozygotes)

immune system

immune system phenotype ( J:119847 )

N • lymphoid organs development is normal

decreased immunoglobulin level ( J:119847 )

decreased IgG1 level ( J:119847 )

• IgG1 levels are lower when re-challenged by NP-CGG

decreased IgM level ( J:119847 )

• IgM levels are decreased during the primary immune response

abnormal T cell physiology ( J:119847 )

• mice have reduced T-cell-dependent primary immune response to 4-hydroxy-3-nitrophenylacetyl coupled to chicken gamma globulin (NP-CGG)

abnormal T cell activation ( J:119847 )

• mice have lower amounts of CD69, a marker of T cell activation

• however, T cell receptor internalization is normal

decreased T cell proliferation ( J:119847 )

• T cell proliferation in response to anti-CD3-mediated TCR signaling is markedly defective

• however, proliferation in response to phorbol 12-myristate 12-acetate and ionomycin was similar to wild-type in in vivo and in vitro assays

• in vitro challenge of enlarged lymph nodes with NP-CGG produces markedly reduced T cell proliferation

decreased interleukin-2 secretion ( J:119847 )

• mice produce less IL-2 after anti-CD3 stimulation

• in vitro challenge of enlarged lymph nodes with NP-CGG shows markedly reduced IL-2 production

behavior/neurological

tremors ( J:119847 )

• slightly trembling hindlimbs

paresis ( J:119847 )

• partial tail paralysis

growth/size/body

decreased body weight ( J:119847 )

reproductive system

reproductive system phenotype ( J:119847 )

N • mice are fertile

hematopoietic system

decreased immunoglobulin level ( J:119847 )

decreased IgG1 level ( J:119847 )

• IgG1 levels are lower when re-challenged by NP-CGG

decreased IgM level ( J:119847 )

• IgM levels are decreased during the primary immune response

abnormal T cell physiology ( J:119847 )

• mice have reduced T-cell-dependent primary immune response to 4-hydroxy-3-nitrophenylacetyl coupled to chicken gamma globulin (NP-CGG)

abnormal T cell activation ( J:119847 )

• mice have lower amounts of CD69, a marker of T cell activation

• however, T cell receptor internalization is normal

decreased T cell proliferation ( J:119847 )

• T cell proliferation in response to anti-CD3-mediated TCR signaling is markedly defective

• however, proliferation in response to phorbol 12-myristate 12-acetate and ionomycin was similar to wild-type in in vivo and in vitro assays

• in vitro challenge of enlarged lymph nodes with NP-CGG produces markedly reduced T cell proliferation

cellular

decreased T cell proliferation ( J:119847 )

• T cell proliferation in response to anti-CD3-mediated TCR signaling is markedly defective

• however, proliferation in response to phorbol 12-myristate 12-acetate and ionomycin was similar to wild-type in in vivo and in vitro assays

• in vitro challenge of enlarged lymph nodes with NP-CGG produces markedly reduced T cell proliferation