homeostasis/metabolism
• diminished platelet serotonin content
|
• significant bleeding defect in platelet function in vivo
• platelet number or size or gross morphology and alpha granule function were normal
|
• impaired aggregation with collage and U46619
|
• reduced secretion of dense granules
|
hematopoietic system
• 50% reduction in the number of dense granules per platelet
|
• diminished platelet serotonin content
|
• impaired aggregation with collage and U46619
|
• reduced secretion of dense granules
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
platelet storage pool deficiency | DOID:2223 |
OMIM:185050 |
J:120307 |